Takeda's trans­la­tion­al cell ther­a­py group revs up for a race to the clin­ic with off-the-shelf CAR-T

Four years af­ter Take­da launched a wide-rang­ing in­duced pluripo­tent stem cell project with the re­searchers at No­bel prize-win­ning Shinya Ya­mana­ka’s lab at the Uni­ver­si­ty of Ky­oto, the phar­ma com­pa­ny is tak­ing de­liv­ery of the first of what it hopes will be a whole pipeline of iPS cell-de­rived ther­a­pies that can de­liv­er on the promise of off-the-shelf CAR-T ther­a­pies.

From here, Ste­fan Wildt — the head of phar­ma sci­ences and trans­la­tion­al cell ther­a­py at Take­da — and his group of 100-plus sci­en­tists will be charged with steer­ing their way to the clin­ic as they build out the man­u­fac­tur­ing and sup­port work for this pipeline-in-the-mak­ing. 

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