R&D

AbbVie concedes another PhIII cancer drug flop as glioblastoma defeats latest assault

One of AbbVie’s top late-stage cancer drugs has flopped in a pivotal trial — the latest victim to hit bottom in the face of glioblastoma.


The pharma giant {$ABBV} noted Friday morning that depatuxizumab mafodotin (or depatux-m; previously known as ABT-414) has been failing to spark a survival benefit in EGFR-amplified cases of the common form of brain cancer in a Phase III study, causing the independent monitors to call it off for the antibody-drug conjugate.


Andrew LassmanThis had been one of AbbVie’s leading late-stage assets in oncology, alongside the bitterly disappointing Rova-T, which has experienced a series of setbacks. AbbVie has had considerable success in cancer with its commercial products and has seen advances with its anti-inflammatories as well. But they took on a tough target when they went after glioblastoma.


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VP Oncology Biology
Skyhawk Therapeutics Waltham, MA
Associate Director CMC
Elektroki Boston, MA
Director Process Development
Elektroki Boston, MA
Research Scientist - Immunology
Recursion Pharmaceuticals Salt Lake City, UT

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