AbbVie gets a big boost in the major league rheumatoid arthritis finals with promising PhIII data
AbbVie passed on a big partnership it had set up with Galapagos on the promising rheumatoid arthritis drug filgotinib so it could focus all of its efforts on an in-house program for upadacitinib (ABT-494). And today the blockbuster gamble was rewarded with a round of stellar data from their first Phase III study of the oral JAK inhibitor.
Both the 15 mg and 30 mg doses swept the primary and secondary endpoints in the study, with 64% and 66% respectively hitting ACR20, with a minimum 20% improvement in the disease score. ACR50 came in at 38% and 43%. Low disease activity was marked by about half of the patients while only 17% of the placebo arm could say the same.
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