Ab­b­Vie hatch­es plans for a ma­jor new R&D hub close to its part­ners in Bay Area's buzzy Oys­ter Point

Ab­b­Vie has signed on to be the first ten­ant of a mas­sive new re­search cen­ter in Oys­ter Point, join­ing a flock of bio­phar­ma peers that’s set up shop in the in­creas­ing­ly pop­u­lar South San Fran­cis­co neigh­bor­hood.

The North Chica­go, IL-based drug­mak­er — whose Stem­cen­tryx sub­sidiary has an op­er­a­tion in the area — is leas­ing al­most 480,000 square feet in the Gate­way of Pa­cif­ic, a 1.4 mil­lion square foot cam­pus un­der con­struc­tion by Bio­Med Re­al­ty. Ink­ing a deal for 10 years, Ab­b­Vie will oc­cu­py a 12-sto­ry tow­er in a space that could even­tu­al­ly hold 1,500 work­ers, the San Fran­cis­co Busi­ness Times re­port­ed.

The new fa­cil­i­ty will “rep­re­sent a Bay Area hub for Ab­b­Vie’s on­col­o­gy busi­ness,” which is cur­rent­ly spread be­tween three dis­tinct lo­ca­tions in the re­gion, Ab­b­Vie spokesper­son Ilke Limon­cu tells End­points News.

“This fu­ture fa­cil­i­ty will al­so fur­ther strength­en our pres­ence in the Bay Area and bring to­geth­er our cur­rent three sites to im­prove col­lab­o­ra­tion and help us grow Ab­b­Vie’s on­col­o­gy sci­ence, re­search, in­no­va­tion and pa­tient care am­bi­tions,” he writes in an email.

The new lo­ca­tion would make Ab­b­Vie a neigh­bor of Genen­tech’s Gate­way cam­pus, while plac­ing it just 10 min­utes away from mul­ti­ple part­ners at Cal­i­co, Cy­tomX and Alec­tor.

When Ab­b­Vie and Cal­i­co re­newed their mon­ster dis­cov­ery deal in June, each com­mit­ting $500 mil­lion more to their al­liance, the Google-backed an­ti-ag­ing biotech made the un­usu­al move to an­nounce that it’s built a team of 150-plus around an HQ base in South San Fran­cis­co, with plans to add more.

Big names and fledg­ling biotechs alike have tak­en a lik­ing to the R&D hub in San Fran­cis­co, with Oys­ter Point in par­tic­u­lar buzzing with new oc­cu­pants. Sang­amo un­veiled plans to build a new HQ right on a ma­ri­na late last year, while As­traZeneca is bring­ing staffers from var­i­ous biotechs it ac­quired to­geth­er at its Cove at Oys­ter Point site.

“The core of Ab­b­Vie’s ini­tia­tive is fo­cused on the tal­ent, in­no­va­tion and cul­ture in the Bay Area,” Di­no Per­az­zo, a rep­re­sen­ta­tive of Ab­b­vie from re­al es­tate bro­ker­age CBRE’s life sci­ence prac­tice, told the San Fran­cis­co Busi­ness Times. “Theirs is the first of what will like­ly be many phar­ma ini­tia­tives com­ing to the Bay Area in the near fu­ture.”

While the the first phase of Gate­way of Pa­cif­ic is ex­pect­ed to com­plete in 2019 — with 431,000 square feet in phase II space to come lat­er — Ab­b­Vie won’t be­gin to move in un­til 2021, when its cur­rent Cal­i­for­nia leas­es ex­pire, Limon­cu con­firms.


Im­age: GATE­WAY OF PA­CIF­IC

Is a pow­er­house Mer­ck team prepar­ing to leap past Roche — and leave Gilead and Bris­tol My­ers be­hind — in the race to TIG­IT dom­i­na­tion?

Roche caused quite a stir at ASCO with its first look at some positive — but not so impressive — data for their combination of Tecentriq with their anti-TIGIT drug tiragolumab. But some analysts believe that Merck is positioned to make a bid — soon — for the lead in the race to a second-wave combo immuno-oncology approach with its own ambitious early-stage program tied to a dominant Keytruda.

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UP­DAT­ED: Leg­end fetch­es $424 mil­lion, emerges as biggest win­ner yet in pan­dem­ic IPO boom as shares soar

Amid a flurry of splashy pandemic IPOs, a J&J-partnered Chinese biotech has emerged with one of the largest public raises in biotech history.

Legend Biotech, the Nanjing-based CAR-T developer, has raised $424 million on NASDAQ. The biotech had originally filed for a still-hefty $350 million, based on a range of $18-$20, but managed to fetch $23 per share, allowing them to well-eclipse the massive raises from companies like Allogene, Juno, Galapagos, though they’ll still fall a few dollars short of Moderna’s record-setting $600 million raise from 2018.

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As it hap­pened: A bid­ding war for an an­tibi­ot­ic mak­er in a mar­ket that has rav­aged its peers

In a bewildering twist to the long-suffering market for antibiotics — there has actually been a bidding war for an antibiotic company: Tetraphase.

It all started back in March, when the maker of Xerava (an FDA approved therapy for complicated intra-abdominal infections) said it had received an offer from AcelRx for an all-stock deal valued at $14.4 million.

The offer was well-timed. Xerava was approved in 2018, four years after Tetraphase posted its first batch of pivotal trial data, and sales were nowhere near where they needed to be in order for the company to keep its head above water.

GSK presents case to ex­pand use of its lu­pus drug in pa­tients with kid­ney dis­ease, but the field is evolv­ing. How long will the mo­nop­oly last?

In 2011, GlaxoSmithKline’s Benlysta became the first biologic to win approval for lupus patients. Nine years on, the British drugmaker has unveiled detailed positive results from a study testing the drug in lupus patients with associated kidney disease — a post-marketing requirement from the initial FDA approval.

Lupus is a drug developer’s nightmare. In the last six decades, there has been just one FDA approval (Benlysta), with the field resembling a graveyard in recent years with a string of failures including UCB and Biogen’s late-stage flop, as well as defeats in Xencor and Sanofi’s programs. One of the main reasons the success has eluded researchers is because lupus, akin to cancer, is not just one disease — it really is a disease of many diseases, noted Al Roy, executive director of Lupus Clinical Investigators Network, an initiative of New York-based Lupus Research Alliance that claims it is the world’s leading private funder of lupus research, in an interview.

Drug man­u­fac­tur­ing gi­ant Lon­za taps Roche/phar­ma ‘rein­ven­tion’ vet as its new CEO

Lonza chairman Albert Baehny took his time headhunting a new CEO for the company, making it absolutely clear he wanted a Big Pharma or biotech CEO with a good long track record in the business for the top spot. In the end, he went with the gold standard, turning to Roche’s ranks to recruit Pierre-Alain Ruffieux for the job.

Ruffieux, a member of the pharma leadership team at Roche, spent close to 5 years at the company. But like a small army of manufacturing execs, he gained much of his experience at the other Big Pharma in Basel, remaining at Novartis for 12 years before expanding his horizons.

Covid-19 roundup: Ab­b­Vie jumps in­to Covid-19 an­ti­body hunt; As­traZeneca shoots for 2B dos­es of Ox­ford vac­cine — with $750M from CEPI, Gavi

Another Big Pharma is entering the Covid-19 antibody hunt.

AbbVie has announced a collaboration with the Netherlands’ Utrecht University and Erasmus Medical Center and the Chinese-Dutch biotech Harbour Biomed to develop a neutralizing antibody that can treat Covid-19. The antibody, called 47D11, was discovered by AbbVie’s three partners, and AbbVie will support early preclinical work, while preparing for later preclinical and clinical development. Researchers described the antibody in Nature Communications last month.

Pfiz­er’s Doug Gior­dano has $500M — and some ad­vice — to of­fer a cer­tain breed of 'break­through' biotech

So let’s say you’re running a cutting-edge, clinical-stage biotech, probably public, but not necessarily so, which could see some big advantages teaming up with some marquee researchers, picking up say $50 million to $75 million dollars in a non-threatening minority equity investment that could take you to the next level.

Doug Giordano might have some thoughts on how that could work out.

The SVP of business development at the pharma giant has helped forge a new fund called the Pfizer Breakthrough Growth Initiative. And he has $500 million of Pfizer’s money to put behind 7 to 10 — or so — biotech stocks that fit that general description.

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UP­DAT­ED: Es­ti­mat­ing a US price tag of $5K per course, remde­sivir is set to make bil­lions for Gilead, says key an­a­lyst

Data on remdesivir — the first drug shown to benefit Covid-19 patients in a randomized, controlled trial setting — may be murky, but its maker Gilead could reap billions from the sales of the failed Ebola therapy, according to an estimate by a prominent Wall Street analyst. However, the forecast, which is based on a $5,000-per-course US price tag, triggered the ire of one top drug price expert.

Bris­tol My­ers is clean­ing up the post-Cel­gene merg­er pipeline, and they’re sweep­ing out an ex­per­i­men­tal check­point in the process

Back during the lead up to the $74 billion buyout of Celgene, the big biotech’s leadership did a little housecleaning with a major pact it had forged with Jounce. Out went the $2.6 billion deal and a collaboration on ICOS and PD-1.

Celgene, though, also added a $530 million deal — $50 million up front — to get the worldwide rights to JTX-8064, a drug that targets the LILRB2 receptor on macrophages.

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