More than a year after its experimental drug, lurbinectedin, failed a late-stage test in platinum-resistant ovarian cancer patients, Spanish biotech PharmaMar on Monday said the agent met the main goal in patients with relapsed small cell lung cancer (SCLC) in a Phase II study.
The primary endpoint of the 105-patient trial was to measure the overall response rate, while secondary goals included progression-free survival and overall survival. Detailed study data will be provided at a future medical meeting, the company said.
Meanwhile, a late-stage study testing lurbinectedin in relapsed SCLC is already underway.
Lung cancer — which encompasses small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) — causes the highest number of cancer-related fatalities globally, the WHO estimates. SCLC, sometimes called oat cell cancer, account for 10% to 15% of all lung cancers, according to the American Cancer Society.
PharmaMar’s drug is designed to inhibit RNA polymerase II, an enzyme key to the transcription process that is over-activated in certain tumors.
The Madrid-based company has a trifecta of oncology programs in clinic for solid cancers (lurbinectedin, PM184 and PM14) apart from Yondelis, an advanced soft-tissue sarcoma and ovarian cancer treatment that it sells in Europe.
The best place to read Endpoints News? In your inbox.
Comprehensive daily news report for those who discover, develop, and market drugs. Join 47,900+ biopharma pros who read Endpoints News by email every day.Free Subscription