AI team at In­sil­i­co gets some ma­jor league back­ing from Chi­na as Alex Zha­voronkov builds glob­al net­work

Some of Asia’s top biotech in­vestors are back­ing Alex Zha­voronkov’s AI shop at In­sil­i­co Med­i­cine.

It’s a long way from a megaround, falling in­to an un­spec­i­fied slot in the $5 mil­lion to $10 mil­lion range, but Zha­voronkov has al­lied him­self with some of the most in­ter­est­ing peo­ple in drug de­vel­op­ment. And he’s us­ing this new mon­ey to ex­pand his glob­al net­work of AI ex­perts as he im­me­di­ate­ly be­gins to go af­ter a new raise to back a big­ger game plan.

Ge Li

This new round is led by WuXi AppTec, the high-fly­ing dis­cov­ery and de­vel­op­ment out­fit based in Shang­hai and helmed by Ge Li, who of­fered an in­flu­en­tial shout out by not­ing that the two com­pa­nies share a “mu­tu­al vi­sion that ar­ti­fi­cial in­tel­li­gence and ma­chine learn­ing will op­ti­mize the drug dis­cov­ery process by in­creas­ing the prob­a­bil­i­ty of suc­cess at the pre-clin­i­cal lev­el.”

Sin­ga­pore’s Temasek al­so got in­volved, along with Pe­ter Dia­man­dis’ — of X Prize fame — BOLD Cap­i­tal. Longevi­ty biotech Ju­ve­nes­cence, backed by UK bil­lion­aire Jim Mel­lon and al­lied with Zha­voronkov’s AI op­er­a­tion, al­so came back to chip in­to the round.

“We have col­lab­o­rat­ed with WuXi for over a year now,” Zha­voronkov tells me, “we know them.”

Be­fore Ge Li and his col­leagues de­cid­ed to back the AI shop, he ex­plained in a pre­view to the an­nounce­ment, they start­ed out a year ago val­i­dat­ing their work us­ing known path­ways. Zha­voronkov has been us­ing ma­chine learn­ing to build mol­e­cules, and he start­ed out by prov­ing that he could do it on projects with well un­der­stood bi­ol­o­gy. Now that they’ve passed that test, WuXi and In­sil­i­co are go­ing in­to vir­gin ter­ri­to­ry, build­ing new mol­e­cules aimed at or­phan tar­gets “from scratch” us­ing a neur­al net­work as they build a new dis­cov­ery plat­form with WuXi’s top chemists.

Zha­voronkov poured every­thing he has in­to the com­pa­ny to get it start­ed, and these grow­ing in­ter­na­tion­al con­nec­tions are cen­tral to build­ing the com­pa­ny. In­sil­i­co now has 52 staffers spread from new of­fices in Rockville, MD in­to Eu­rope, Rus­sia and Asia, where a team of 6 work in Tai­wan. His next step, he says, is aimed right at the ex­plod­ing Chi­nese mar­ket.

In AI, he says, “if you’re not in Chi­na now, you’re not go­ing to ex­ist.”

In the mean­time, he’s fo­cused on build­ing his busi­ness de­vel­op­ment team, look­ing to re­cruit some new play­ers.

AI shops have been boom­ing is a va­ri­ety of big op­er­a­tions con­sid­er the ways the tech­nol­o­gy can be used to stream­line drug de­vel­op­ment and im­prove odds of suc­cess — a propo­si­tion that still has a con­sid­er­able ways to go be­fore we start see­ing how it can af­fect the out­put of new drugs that go in­to hu­man test­ing. For big com­pa­nies deeply en­gaged in dis­cov­ery, though, it re­mains a com­pelling ap­proach to pipeline build­ing.

Just a few weeks ago Zha­voronkov al­lied with George Church on a col­lab­o­ra­tion mix­ing Neb­u­la Ge­nomics’ blockchain work with his deep learn­ing ex­perts to build a new plat­form for health­care da­ta. And he con­tin­ues to build re­la­tions with some of the most close­ly watched de­vel­op­ers in the in­dus­try, in­clud­ing Glax­o­SmithK­line.

Im­age: Alex Zha­voronkov. HEALTH TECH­NOLO­GIES TV via YOUTUBE

Jim Mellon [via YouTube]

Health­i­er, longer lifes­pans will be a re­al­i­ty soon­er than you think, Ju­ve­nes­cence promis­es as it clos­es $100M round

Earlier this year, an executive from Juvenescence-backed AgeX predicted the field of longevity will eventually “dwarf the dotcom boom.” Greg Bailey, the UK-based anti-aging biotech’s CEO, certainly hopes so.

On Monday, Juvenescence completed its $100 million series B round of financing. The company is backed by British billionaire Jim Mellon — who wrote his 400-page guide to investing in the field of longevity shortly after launching the company in 2017.  Bailey, who served as a board director for seven years at Medivation before Pfizer swallowed the biotech for $14 billion, is joined by Declan Doogan, an industry veteran with stints at Pfizer and Amarin.

John Hood [file photo]

UP­DATE: Cel­gene and the sci­en­tist who cham­pi­oned fe­dra­tinib's rise from Sanofi's R&D grave­yard win FDA OK

Six years after Sanofi gave it up for dead, the FDA has approved the myelofibrosis drug fedratinib, now owned by Celgene.

The drug will be sold as Inrebic, and will soon land in the portfolio at Bristol-Myers Squibb, which is finalizing a deal to acquire Celgene.

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UP­DAT­ED: AveX­is sci­en­tif­ic founder was axed — and No­var­tis names a new CSO in wake of an ethics scan­dal

Now at the center of a storm of controversy over its decision to keep its knowledge of manipulated data hidden from regulators during an FDA review, Novartis CEO Vas Narasimhan has found a longtime veteran in the ranks to head the scientific work underway at AveXis, where the incident occurred. And the scientific founder has hit the exit.

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Ab­b­Vie gets its FDA OK for JAK in­hibitor upadac­i­tinib, but don’t look for this one to hit ex­ecs’ lofty ex­pec­ta­tions

Another big drug approval came through on Friday afternoon as the FDA OK’d AbbVie’s upadacitinib — an oral JAK1 inhibitor that is hitting the rheumatoid arthritis market with a black box warning of serious malignancies, infections and thrombosis reflecting fears associated with the class.

It will be sold as Rinvoq — at a wholesale price of $59,000 a year — and will likely soon face competition from a drug that AbbVie once controlled, and spurned. Reuters reports that a 4-week supply of Humira, by comparison, is $5,174, adding up to about $67,000 a year.

The top 10 fran­chise drugs in bio­phar­ma his­to­ry will earn a to­tal of $1.4T (tril­lion) by 2024 — what does that tell us?

Just in case you were looking for more evidence of just how important Amgen’s patent win on Enbrel is for the company and its investors, EvaluatePharma has come up with a forward-looking consensus estimate on what the list of top 10 drugs will look like in 2024.

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UP­DAT­ED: Sci­en­tist-CEO ac­cused of im­prop­er­ly us­ing con­fi­den­tial in­fo from uni­corn Alec­tor

The executive team at Alector $ALEC has a bone to pick with scientific co-founder Asa Abeliovich. Their latest quarterly rundown has this brief note buried inside:

On June 18, 2019, we initiated a confidential arbitration proceeding against Dr. Asa Abeliovich, our former consulting co-founder, related to alleged breaches of his consulting agreement and the improper use of our confidential information that he learned during the course of rendering services to us as our consulting Chief Scientific Officer/Chief Innovation Officer. We are in the early stage of this arbitration proceeding and are unable to assess or provide any assurances regarding its possible outcome.

There’s no explicit word in the filing on what kind of confidential info was involved, but the proceeding got started 2 days ahead of Abeliovich’s IPO.

Abeliovich, formerly a tenured associate professor at Columbia, is a top scientist in the field of neurodegeneration, which is where Alector is targeted. More recently, he’s also helped start up Prevail Therapeutics as the CEO, which raised $125 million in an IPO. And there he’s planning on working on new gene therapies that target genetically defined subpopulations of Parkinson’s disease. Followup programs target Gaucher disease, frontotemporal dementia and synucleinopathies.

But this time Abeliovich is the CEO rather than a founding scientist. And some of their pipeline overlaps with Alector’s.

Abeliovich and Prevail, though, aren’t taking this one lying down.

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Chi­na has be­come a CEO-lev­el pri­or­i­ty for multi­na­tion­al phar­ma­ceu­ti­cal com­pa­nies: the trend and the im­pli­ca­tions

After a “hot” period of rapid growth between 2009 and 2012, and a relatively “cooler” period of slower growth from 2013 to 2015, China has once again become a top-of-mind priority for the CEOs of most large, multinational pharmaceutical companies.

At the International Pharma Forum, hosted in March in Beijing by the R&D Based Pharmaceutical Association Committee (RDPAC) and the Pharmaceutical Research and Manufacturers of America (PhRMA), no fewer than seven CEOs of major multinational pharmaceutical firms participated, including GSK, Eli Lilly, LEO Pharma, Merck KGaA, Pfizer, Sanofi and UCB. A few days earlier, the CEOs of several other large multinationals attended the China Development Forum, an annual business forum hosted by the research arm of China’s State Council. It’s hard to imagine any other country, except the US, having such drawing power at CEO level.

As dis­as­ter struck, Ab­b­Vie’s Rick Gon­za­lez swooped in on Al­ler­gan with an of­fer Brent Saun­ders couldn’t say no to

Early March was a no good, awful, terrible time for Allergan CEO Brent Saunders. His big lead drug had imploded in a Phase III disaster and activists were after his hide — or at least his chairman’s title — as the stock price continued a steady droop that had eviscerated share value for investors.

But it was a perfect time for AbbVie CEO Rick Gonzalez to pick up the phone and ask Saunders if he’d like to consider a “strategic” deal.

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CEO Pascal Soriot via Getty Images

As­traZeneca's jug­ger­naut PARP play­er Lyn­parza scoops up an­oth­er dom­i­nant win in PhI­II as the FDA adds a 'break­through' for Calquence

AstraZeneca’s oncology R&D group under José Baselga keeps churning out hits.

Wednesday morning the pharma giant and their partners at Merck parted the curtains on a successful readout for their Phase III PAOLA-1 study, demonstrating statistically significant improvement in progression-free survival for women with ovarian cancer in a first-line maintenance setting who added their PARP Lynparza to Avastin. This is their second late-stage success in ovarian cancer, which will help stave off rivals like GSK.

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