Al­ler­gan’s $560M buy­out deal just led to a PhI­II de­ba­cle as an­oth­er de­pres­sion drug goes down to bit­ter de­feat

Al­ler­gan’s $560 mil­lion deal to buy Nau­rex has led it straight down a blind al­ley for de­pres­sion drugs, where it’s been mugged by a de­ci­sive set of failed late-stage da­ta.

Brent Saun­ders’ biotech $AGN an­nounced af­ter the mar­ket closed that ra­pastinel had flunked the big set of Phase III stud­ies used to test the drug for ma­jor de­pres­sion. Topline re­sults from 3 Phase III tri­als along with a late-stage test on re­laps­es proved con­clu­sive­ly that the drug had none of its in­tend­ed ef­fects — ei­ther on the pri­ma­ry or sec­ondary end­points.

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