Am­gen sells its Turk­ish man­u­fac­tur­ing arm for $135M

Phar­ma gi­ant Am­gen has de­cid­ed to sell off its Turk­ish man­u­fac­tur­ing arm for nine fig­ures.

The Ecza­cıbaşı Group has ac­quired Gensen­ta from the Cal­i­for­nia-based phar­ma. The deal will see Ecza­cıbaşı pay $135 mil­lion for a 99.96% stake in the com­pa­ny. The pur­chase of Gensen­ta will be fi­nal­ized af­ter it gets ap­proval from the Turk­ish Com­pe­ti­tion Au­thor­i­ty.

Ac­cord­ing to Ecza­cıbaşı, Am­gen Turkey will con­tin­ue to keep its op­er­a­tions run­ning and serve its cus­tomers.

Bü­lent Ecza­cıbaşı

“This ac­qui­si­tion fu­els our growth by adding lo­cal pro­duc­tion ca­pa­bil­i­ties in phar­ma­ceu­ti­cals, biosim­i­lar prod­ucts, and ac­tive in­gre­di­ents to our in­vest­ment port­fo­lio as well as ex­port com­pe­ten­cy,” said Bü­lent Ecza­cıbaşı, the chair­per­son at Ecza­cıbaşı Hold­ing, in a state­ment.

Ecza­cıbaşı is a Turk­ish in­dus­tri­al group that owns 46 com­pa­nies and is al­so the founder of Turkey’s first mod­ern phar­ma­ceu­ti­cal man­u­fac­tur­ing plant in 1952. Their man­u­fac­tur­ing arm in­cludes the mak­ing of orig­i­nal drugs and non-pre­scrip­tion prod­ucts.

The deal to sell Gensen­ta is a ma­jor one for Turkey as the na­tion’s old­est phar­ma­ceu­ti­cal com­pa­ny. Gensen­ta was found­ed as a lab­o­ra­to­ry in 1923 and in­cor­po­rat­ed as Mustafa Nevzat Phar­ma­ceu­ti­cals in 1957. The com­pa­ny was ac­quired by Am­gen in 2012 and in 2020 was re­named Gensen­ta.

Gensen­ta is a pow­er­house for phar­ma­ceu­ti­cal ex­port from Turkey and in the man­u­fac­tur­ing of APIs and fin­ished dosage forms.

Gensen­ta has two man­u­fac­tur­ing fa­cil­i­ties lo­cat­ed in Yeni­bosna, one of the main in­dus­tri­al ar­eas of Is­tan­bul. This in­cludes sep­a­rate plants for fin­ished dosage forms as well as an­tibi­otics and an­ti-can­cer prod­ucts, among oth­ers.

This deal comes at a time when Am­gen is putting more of its man­u­fac­tur­ing ca­pa­bil­i­ties in the Unit­ed States, es­pe­cial­ly in North Car­oli­na, as it broke ground in March on a $550 mil­lion drug sub­stance plant.

For Turkey, a re­port from the US­TR in March said that stake­hold­ers raised con­cerns re­gard­ing the coun­try’s phar­ma­ceu­ti­cal man­u­fac­tur­ing in­spec­tion process and urged Turkey to build up­on its ac­ces­sion to the Phar­ma­ceu­ti­cal In­spec­tion Con­ven­tion and Co-op­er­a­tion Scheme (PIC/S) and to rec­og­nize GMP cer­tifi­cates is­sued by any of the PIC/S mem­bers to im­prove reg­u­la­to­ry time­lines.

The Fac­tors Dri­ving a Rapid Evo­lu­tion of Gene & Cell Ther­a­py and CAR-T Clin­i­cal Re­search in APAC

APAC is the fastest growing region globally for cell & gene therapy trials representing more than a third of all cell & gene studies globally, with China leading in the region. 

APAC is the leading location globally for CAR-T trials with China attracting ~60% of all CAR-T trials globally between 2015-2022. The number of CAR-T trials initiated by Western companies has rapidly increased in recent years (current CAGR of about 60%), with multiple targets being explored including CD19, CD20, CD22, BCMA, CD30, CD123, CD33, CD38, and CD138.

The End­points 11; blue­bird's $3M gene ther­a­py; Bio­gen tout new neu­ro da­ta; Harsh re­views for can­cer drugs; and more

Welcome back to Endpoints Weekly, your review of the week’s top biopharma headlines. Want this in your inbox every Saturday morning? Current Endpoints readers can visit their reader profile to add Endpoints Weekly. New to Endpoints? Sign up here.

Reading about John Carroll’s pick of biotech’s most promising startups has become a treasured tradition. If you ever get curious about previous classes of the Endpoints 11, you can find all of them (plus a number of our other regular specials) here.

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EMA warns of short­ages of two Boehringer heart drugs due to a spike in de­mand

The EMA is putting EU member states on alert over the shortage of two drugs that counter heart attacks due to an uptick in demand.

On Friday, the EMA sent out a warning that two Boehringer Ingelheim drugs are experiencing a shortage: Actilyse and Metalyse. The drugs are used as emergency treatments for adults experiencing acute myocardial infarction, or a heart attack, by dissolving blood clots that have formed in the blood vessels.

The End­points 11: The top pri­vate biotechs in pur­suit of new drugs. Push­ing the en­ve­lope with pow­er­ful new tech­nolo­gies

Right around the beginning of the year, we got a close-up look at what happens after a boom ripples through biotech. The crash of life sciences stocks in Q1 was heard around the world.

In the months since, we’ve seen the natural Darwinian down cycle take effect. Reverse mergers made a comeback, with more burned out shells to go public at a time IPOs and road shows are out of favor. And no doubt some of the more recent arrivals on the investing side of the business are finding greener pastures.

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Luke Miels, GSK chief commercial officer

Lend­ing a hand to a biotech in trou­ble, GSK drops $75M cash to add late-stage an­tibi­ot­ic to port­fo­lio

GSK likes to take pride in being one of the few Big Pharma players still active in antibiotics R&D. And that means keeping tabs on what the field has to offer.

In a move to beef up the late-stage pipeline, GSK is licensing a late-stage antibiotic candidate from Spero Therapeutics. In doing so, it’s coming to the rescue of a struggling biotech that’s crumbled in the wake of an FDA rejection and raised doubts about its ability to carry on.

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David Chang, Allogene CEO (Jeff Rumans)

Servi­er cuts off col­lab­o­ra­tion agree­ment with Al­lo­gene on CD19 prod­ucts, send­ing shares sput­ter­ing

Allogene Therapeutics said in an SEC filing today that French partner Servier has cut off its involvement in a partnership developing therapies directed against CD19, including the most advanced candidates in Allogene’s pipeline.

Shares of Allogene $ALLO, an outfit run by Kite vets Arie Belldegrun and research chief David Chang, fell by almost 10% on Wednesday, even as the San Francisco-based company said that Servier’s discontinuation “does not otherwise affect our current exclusive license for the development and commercialization of CD19 Products in the United States.”

Rahul Singhvi, Resilience CEO

Q&A: Re­silience boss Rahul Singhvi talks $2B US bio­man­u­fac­tur­ing ini­tia­tive and post Se­ries D deals

When the Biden administration announced last week, through an executive order, that it is investing $2 billion into domestic efforts to increase biotechnology and biomanufacturing efforts, a lot of ears perked up in the wider manufacturing world. Funding is going towards manufacturing infrastructure, training, R&D and security measures, among others, something that domestic manufacturers are bullish about.

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Lina Khan, FTC chair (Graeme Sloan/Sipa USA/Sipa via AP Images)

FTC chair Lina Khan to Sen­ate: Big Phar­ma M&A is still a pri­or­i­ty tar­get

As the Federal Trade Commission has already sought new ideas for analyzing pharma mergers, FTC chair Lina Khan reiterated Tuesday to a Senate subcommittee that reviewing Big Pharma mergers is a priority.

While comparing this merger analysis in the pharma space to the study of public utilities in the 1930s “that exposed rampant financial fraud,” Khan said in prepared testimony that the commission is going to target unlawful conduct.

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Armed with cash, Bel­gian iP­SC play­er makes a play for Celyad’s cell ther­a­py man­u­fac­tur­ing site

A Belgian cell therapy player has netted a deal close to home.

Ncardia, a Belgium-based contract research company, spun out its cell therapy and manufacturing arm in April into a company called Cellistic. Now, the spin-out has acquired an 11,000-square-foot facility in the town of Mont-Saint-Guibert, Belgium, for the price of €6 million ($5.9 million) from Celyad Oncology. The deal is expected to close in Q2 of this year.