As safety looms larger in CAR-T research, study highlights how small tweaks can make it easier to use
For all the promises of CAR-T therapy, significant side effects — notably life-threatening episodes of cytokine release syndrome and neurotoxicity — have limited its use in closely monitored settings. As researchers seek new approaches to tamp down safety concerns, a small clinical trial published in Nature Medicine has offered the first glimpse of hope that small tweaks on existing molecules can make CAR-T safer while maintaining its cancer killing ability.
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