As­traZeneca, Mer­ck­'s star PARP in­hibitor Lyn­parza ex­pands reach in ovar­i­an can­cer with new US ap­proval

Weeks af­ter GSK widened the mar­ket for PARP in­hibitor Ze­ju­la in pa­tients with ovar­i­an can­cer, ri­val As­traZeneca’s mar­ket-lead­ing Lyn­parza has al­so se­cured ex­pand­ed use in women with the dis­ease.

Lyn­parza, in com­bi­na­tion with Roche’s Avastin, has been ap­proved by the FDA for the main­te­nance treat­ment of adult pa­tients with ad­vanced ep­ithe­lial ovar­i­an, fal­lop­i­an tube or pri­ma­ry peri­toneal can­cer who have ex­pe­ri­enced a com­plete or par­tial re­sponse to first-line plat­inum-based chemother­a­py and whose dis­ease is as­so­ci­at­ed with ho­mol­o­gous re­com­bi­na­tion de­fi­cien­cy (HRD) pos­i­tive sta­tus, de­fined by ei­ther a BR­CA mu­ta­tion and/or ge­nom­ic in­sta­bil­i­ty. Rough­ly one in two women with ad­vanced ovar­i­an can­cer has an HRD+ tu­mor.

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