At the cen­ter of a glob­al tem­pest, Jiankui He de­fends edit­ing the genes of 2 new­borns

HONG KONG — Fac­ing a storm of crit­i­cism from some of the med­ical world’s best known ex­perts and un­der in­ves­ti­ga­tion by Chi­nese of­fi­cials for pro­duc­ing the world’s first gene-edit­ed ba­bies in a self-fund­ed ex­per­i­ment that has spurred head­lines around the world, Jiankui He took to the cen­ter stage of a promi­nent sci­en­tif­ic con­fer­ence in Hong Kong to de­fend his work.

Calm­ly and clear­ly, He out­lined his project us­ing CRISPR to dis­able a key gene in or­der to con­fer im­mu­ni­ty to HIV for the new­borns — who were ex­posed to the threat by an HIV-pos­i­tive par­ent — and of­fered an apol­o­gy as the news that he had al­tered em­bryos “leaked un­ex­pect­ed­ly” be­fore he could present it at a sci­en­tif­ic venue.

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