Eli Lil­ly, Pfiz­er cel­e­brate a PhI­II suc­cess for their block­buster pain drug con­tender tanezum­ab -- but ques­tions linger

Five years af­ter Eli Lil­ly stepped up with a $1.8 bil­lion deal to bring Pfiz­er’s an­ti-NGF pain drug tanezum­ab back from lim­bo, the phar­ma gi­ants are re­port­ing that they suc­cess­ful­ly nav­i­gat­ed a ma­jor Phase III study for the non-opi­oid ther­a­py among pa­tients suf­fer­ing from os­teoarthri­tis.

Re­searchers say that their drug hit three pri­ma­ry end­points for pain, phys­i­cal func­tion and the pa­tients’ over­all as­sess­ment of their OA. Tapped by Pfiz­er as one of the lead­ing late-stage drugs in their pipeline, the in­ves­ti­ga­tors al­so not­ed that “rapid­ly pro­gres­sive os­teoarthri­tis was ob­served in tanezum­ab-treat­ed pa­tients at a fre­quen­cy of less than 1.5%, and was not ob­served in the place­bo arm.”

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