Bay­er to cut in­ter­nal drug R&D work, ax­ing hun­dreds of re­searchers while look­ing to part­ners as it un­veils plan to slash 12,000 jobs

Bay­er is push­ing ahead with plans to re­struc­ture its drug R&D busi­ness and cut 900 re­search staffers as part of a broad plan to slash a to­tal of 12,000 em­ploy­ees in a world­wide re­vamp.

De­tails on the changes in R&D — some­thing that’s been ru­mored to be in the works for months — are slim, with no word about which projects are threat­ened. Their state­ment notes 900 jobs are be­ing cut in phar­ma R&D with an­oth­er 350 jobs slashed at a Ger­man fac­tor VI­II pro­duc­tion plant. The em­pha­sis now will shift in drug R&D, re­duc­ing in-house work while look­ing to ex­ter­nal part­ners to car­ry more of the load.

In their state­ment the Ger­man phar­ma com­pa­ny says that their R&D “mea­sures in­clude ac­cel­er­at­ed de­vel­op­ment of the in­no­va­tion mod­el and a re­struc­tur­ing of in­ter­nal R&D ac­tiv­i­ties. Re­sources freed up through the re­duc­tion of in­ter­nal ca­pac­i­ties are to be di­rect­ed to­ward strength­en­ing in­vest­ment in col­lab­o­ra­tive re­search mod­els and ex­ter­nal in­no­va­tions.”

Bay­er al­so plans to sell off con­sumer prod­ucts and ex­it the an­i­mal health busi­ness fol­low­ing its ac­qui­si­tion of Mon­san­to — which faces its own in­ter­nal cuts as a bliz­zard of law­suits be­siege the new own­ers.

With Roche shak­ing up the he­mo­phil­ia mar­ket with its new drug Hem­li­bra, Bay­er says that it will shut­ter “the fac­tor VI­II fa­cil­i­ty it has built in Wup­per­tal, Ger­many, and … fo­cus all re­com­bi­nant fac­tor VI­II pro­duc­tion in Berke­ley,” CA.

Ru­mors about a big shake­up in R&D have been cir­cu­lat­ing through much of 2018. Ger­many’s Wirtschaftswoche got it start­ed at the end of May, re­port­ing that the prospec­tive cuts could reach up to 1,000 in the re­or­ga­ni­za­tion. Reuters then re­port­ed that job cuts and out­sourc­ing were on the ta­ble as the Ger­man drug com­pa­ny looks to raise more cash to in-li­cense new ther­a­pies for its pipeline.

Com­mu­ni­cat­ing the val­ue of pre­ci­sion med­i­cine

By Natasha Cowan, Content Marketing Manager at Blue Latitude Health.
Many stakeholders are confused by novel precision medicines, including patients and healthcare professionals. So, how can industry help them to navigate this complexity?

Precision medicine represents a new paradigm in healthcare. It embodies the shift from treating many patients with the same therapy, to having the tools to identify the best treatment for every patient.

Mer­ck buys a fledg­ling neu­rode­gen­er­a­tive biotech spawned by an old GSK dis­cov­ery al­liance. What’s up with that?

Avalon Ventures chief Jay Lichter has a well-known yen for drug development programs picked up in academia. And what he found in Haoxing Xu’s lab at the University of Michigan pricked his interest enough to launch one of his umbrella biotechs in San Diego.
Xu’s work laid the foundation for Avalon to launch Calporta, which has been working on finding small molecule agonists of TRPML1 (transient receptor potential cation channel, mucolipin subfamily, member 1) for lysosomal storage disorders. And that pathway, they believe, points to new approaches on major market neurodegenerative diseases like Parkinson’s, ALS and Alzheimer’s.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 65,400+ biopharma pros reading Endpoints daily — and it's free.

In­vestors could emerge from Neil Wood­ford de­ba­cle with £1B loss, in­ter­nal analy­sis re­veals

When Link Fund Solutions announced that it is closing Woodford Equity Income Fund permanently and kicking out Neil Woodford, it was implied that investors probably won’t get back everything they entrusted to the fund manager. But nobody knew just how much they would lose.

An internal analysis commissioned by Link suggested that the collective loss could amount to £1 billion — out of a fund last valued at £3.1 billion — Citywire has revealed.

GSK's asth­ma bi­o­log­ic Nu­cala scores in rare blood dis­or­der study

GlaxoSmithKline’s asthma drug Nucala, which received a resounding FDA rejection for use in chronic obstructive pulmonary disease (COPD) last year, has shown promise in a rare blood disorder.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 65,400+ biopharma pros reading Endpoints daily — and it's free.

Spe­cial re­port: Twen­ty ex­tra­or­di­nary women in bio­phar­ma R&D who worked their way to the top

What differentiates a woman leader in biopharma R&D from a man?

Not much, except there are fewer of them in senior posts. Data suggest women are not more risk-averse, family-oriented or less confident than their male counterparts — indeed the differences between the two sexes are negligible. But a glance at the top R&D positions in Big Pharma leaves little doubt that upward migration in the executive ranks of biopharma R&D is tough.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 65,400+ biopharma pros reading Endpoints daily — and it's free.

FDA Vas­cepa re­view spot­lights new safe­ty sig­nals, pos­si­ble min­er­al oil spoil­er as Amarin hunts a block­buster ap­proval

An in-house FDA review of Amarin’s Vascepa raises a set of hurdles the biotech will have to clear if the biotech expects to get the long-awaited FDA approval that could set it on a path to superstar status. But it appears that Amarin has survived another potential setback without introducing a major new threat to its prospects.

The stakes don’t get much higher, with analysts saying a win this week for Amarin could lead to billions in new sales — provided the agency stamps it with an OK. And investors liked what they say in the FDA review this morning, bumping the stock $AMRN 17%.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 65,400+ biopharma pros reading Endpoints daily — and it's free.

FDA puts Sol­id Bio’s lead gene ther­a­py pro­gram on hold — again — af­ter an­oth­er pa­tient is hurt by SGT-001

Solid Biosciences continues to be plagued by safety issues.

Close to 18 months after the gene therapy biotech was able to quickly shed an FDA hold on their lead Duchenne muscular dystrophy program for SGT-001, regulators have stepped back in to force another halt after another patient was hit hard by a set of serious adverse events remarkably similar to the first set.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 65,400+ biopharma pros reading Endpoints daily — and it's free.

FDA slaps a hold on an AML tri­al as Mark­er scraps a fail­ing ovar­i­an can­cer pro­gram, sink­ing shares

The FDA has placed a hold on a Phase II AML trial from the small immuno-oncology biotech Marker Therapeutics. Marker disclosed the issue two weeks after responding to FDA concerns, adding it to the Q3 release Tuesday. The company also announced it was scrapping a Phase II ovarian cancer program it determined was unlikely to succeed.

The agency’s concern centers around two reagents used in manufacturing for their trial for acute myeloid leukemia patients who have received a stem cell transplant. The reagents are from third parties and not present in the final product, Marker said.

Eli Lil­ly-backed biotech grabs $100M to dis­patch an­ti­body-oligonu­cleotide con­ju­gates af­ter mus­cu­lar dy­s­tro­phy

Hold up your hand. Make a fist. Now open it. And again.

If you can do it fully and with ease, then the proteins in your hand are likely working properly. If you can’t then they may not be. In people with myotonic muscular dystrophy, something more atomic is going on.

In those folks, the problem is RNA. Certain base pairs repeat far beyond normal, up to 11,000 superfluous letters in some cases. The extended strands form “clumps.” Proteins misform and can’t function properly. They often allow one movement but not the reverse, a condition called myotonia that gives the dystrophy its name.