Drug Development

Bial accused of negligence in lethal drug trial — Nature

David Webb, president of the British Pharmacological Society, says that new revelations at a recent conference proved that the investigators from Portuguese biotech Bial were “flying blind” when they started a trial which left one patient dead and four others with lingering neurological damage.

The revelation, reports Nature, is that Bial overlooked the pharmacodynamic data on a low dose of BIA 10-2474 before taking the dose higher.

“Without the PD data, they were flying blind. That’s when accidents happen,” says Webb. “I think that was negligent.”

Bial, though, denies the allegation:

“All official reports about the trial were inconclusive and all have considered this event as unpredictable, and that there was no indication whatsoever, including in the pre-trials, that could have predicted this outcome.”

The best place to read Endpoints News? In your inbox.

Comprehensive daily news report for those who discover, develop, and market drugs. Join 47,200+ biopharma pros who read Endpoints News by email every day.

Free Subscription

Research Scientist - Immunology
Recursion Pharmaceuticals Salt Lake City, UT
Director of Operations
Atlas Venture Cambridge, MA

Visit Endpoints Careers ->