Bio­gen hit by ALS set­back with PhI­II fail­ure for tofersen — but fol­lows a fa­mil­iar strat­e­gy high­light­ing the pos­i­tive

Pa­tients and an­a­lysts wait­ing to hear Sun­day how Bio­gen’s SOD1-ALS drug tofersen fared in Phase III didn’t have to wait long for the top-line re­sult they were all wait­ing for. The drug failed the pri­ma­ry end­point on sig­nif­i­cant­ly im­prov­ing the func­tion­al and neu­ro­log­ic de­cline of pa­tients over 28 weeks as well as the ex­ten­sion pe­ri­od for con­tin­ued ob­ser­va­tion.

In fact, there was very lit­tle dif­fer­ence in re­sponse.

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