Bristol-Myers bags a new tumor microenvironment drug for next-gen cancer combos
A little more than three years ago, Genmab outlicensed its HuMax IL-8 targeting antibody to little Cormorant Pharmaceuticals in Stockholm. Over recent years, investigators have been plumbing IL-8, looking at the ways IL-8 signaling influences the tumor microenvironment, promoting inflammation, assisting in cancer cell survival and promoting their migration.
That mechanism could play a role in a new wave of immuno-oncology drugs headed to the clinic – which helped attract the NCI into the early-stage program. And now Bristol-Myers Squibb, which leads the immuno-oncology field with its dominant drug Opdivo, wants it.
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