Cam­bridge fund rais­es more than $196M in the UK's hefti­est 2019 fund­ing round

Less than two years af­ter its last fund­ing round, the ven­ture fund as­so­ci­at­ed with the Uni­ver­si­ty of Cam­bridge has raised a meaty £150 mil­lion ($196.4 mil­lion) — in the UK’s largest fund­ing round of 2019 — more than dou­bling the fi­nan­cial re­sources avail­able to the en­ti­ty, Cam­bridge In­no­va­tion Cap­i­tal (CIC).

Vic­tor Chris­tou

Since its in­cep­tion in 2013, CIC has raised £275 mil­lion to in­vest in a web of life sci­ence and tech com­pa­nies — in­clud­ing those fo­cused on sur­gi­cal ro­bot­ics, flex­i­ble elec­tron­ics, mi­cro­bio­me sci­ence, ge­nomics and AI soft­ware — with­in the ta­pes­try of Cam­bridge, in­clud­ing but not lim­it­ed to Uni­ver­si­ty of Cam­bridge spin-offs.

Cam­bridge, UK is an in­te­gral part of the Gold­en Tri­an­gle, which loops in Ox­ford with the big Lon­don ax­is and is home to As­traZeneca’s cam­pus. As of the first quar­ter of 2019, the area hous­es 258 ac­tive biotech R&D busi­ness­es, up 77% from 2016, ac­cord­ing to an analy­sis from Lon­don-based in­vest­ment man­ag­er Down­ing.

CIC — which counts the uni­ver­si­ty, as well as its en­dow­ment fund com­bined as its largest share­hold­er — has in­ject­ed £125 mil­lion in cap­i­tal in­to 25 firms so far. Most re­cent­ly, it par­tic­i­pat­ed in a £40 mil­lion se­ries B round for liq­uid biop­sy com­pa­ny Ini­va­ta — spun out from Can­cer Re­search UK and Cam­bridge Uni­ver­si­ty — last week. CIC has al­so in­vest­ed in Ab­co­dia, which is work­ing on bio­mark­ers for the ear­ly de­tec­tion and screen­ing of can­cer, as well as Eu­ro­pean on­col­o­gy com­pa­ny Car­rick Ther­a­peu­tics.

Out­side of biotech, CIC has been busy in the first quar­ter, mak­ing in­vest­ments in low-cost flex­i­ble elec­tron­ics mak­er Prag­mat­IC, video man­age­ment plat­form busi­ness Im­a­gen and spa­tial big da­ta com­pa­ny GeoSpock.

When the in­vest­ment ve­hi­cle was set up, CIC had aimed to raise more via an IPO af­ter rais­ing mon­ey over two-to-three years. Ahead of the lat­est raise, chief ex­ec­u­tive Vic­tor Chris­tou told the Fi­nan­cial Times that that CIC de­cid­ed to re­main pri­vate af­ter re­view­ing its op­tions. “Look­ing at what has hap­pened in the pub­lic mar­kets re­cent­ly, I feel vin­di­cat­ed in our de­ci­sion. An IPO re­mains an op­tion in the long term but not in the near fu­ture.”

Sanofi brings in 4 new ex­ec­u­tives in con­tin­ued shake-up, as vac­cines and con­sumer health chief head out the door

In the middle of Sanofi’s multi-pronged race to develop a Covid-19 vaccine, David Loew, the head of their sprawling vaccines unit, is leaving – part of the final flurry of moves in the French giant’ months-long corporate shuffle that will give them new-look leadership under new CEO Paul Hudson.

The company also said today that Alan Main, the head of their consumer healthcare unit, is out, and they named 4 executives to fill new or newly vacated positions, 3 of whom come from both outside both Sanofi and from Pharma.

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As­traZeneca trum­pets the 'mo­men­tous' da­ta they found for Tagris­so in an ad­ju­vant set­ting for NSCLC — but many of the ex­perts aren’t cheer­ing along

AstraZeneca is rolling out the big guns this evening to provide a salute to their ADAURA data on Tagrisso at ASCO.

Cancer R&D chief José Baselga calls the disease-free survival data for their drug in an adjuvant setting of early stage, epidermal growth factor receptor-mutated NSCLC patients following surgery “momentous.” Roy Herbst, the principal investigator out of Yale, calls it “transformative.”

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Pablo Legorreta, founder and CEO of Royalty Pharma AG, speaks at the annual Milken Institute Global Conference in Beverly Hills, California (Patrick T. Fallon/Bloomberg via Getty Images)

Cap­i­tal­iz­ing Pablo: The world’s biggest drug roy­al­ty buy­er is go­ing pub­lic. And the low-key CEO di­vulges a few se­crets along the way

Pablo Legorreta is one of the most influential players in biopharma you likely never heard of.

Over the last 24 years, Legorreta’s Royalty Pharma group has become, by its own reckoning, the biggest buyer of drug royalties in the world. The CEO and founder has bought up a stake in a lengthy list of the world’s biggest drug franchises, spending $18 billion in the process — $2.2 billion last year alone. And he’s become one of the best-paid execs in the industry, reaping $28 million from the cash flow last year while reserving 20% of the cash flow, less expenses, for himself.

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Dan O'Day, Gilead CEO (Andrew Harnik, AP Images)

UP­DAT­ED: Gilead leas­es part­ner rights to TIG­IT, PD-1 in a $2B deal with Ar­cus. Now comes the hard part

Gilead CEO Dan O’Day has brokered his way to a PD-1 and lined up a front row seat in the TIGIT arena, inking a deal worth close to $2 billion to align the big biotech closely with Terry Rosen’s Arcus. And $375 million of that comes upfront, with cash for the buy-in plus equity, along with $400 million for R&D and $1.22 billion in reserve to cover opt-in payments and milestones..

Hotly rumored for weeks, the 2 players have formalized a 10-year alliance that starts with rights to the PD-1, zimberelimab. O’Day also has first dibs on TIGIT and 2 other leading programs, agreeing to an opt-in fee ranging from $200 million to $275 million on each. There’s $500 million in potential TIGIT milestones on US regulatory events — likely capped by an approval — if Gilead partners on it and the stars align on the data. And there’s another $150 million opt-in payments for the rest of the Arcus pipeline.

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Paul Hudson, Sanofi CEO (Getty Images)

Sanofi CEO Paul Hud­son has $23B burn­ing a hole in his pock­et. And here are some hints on how he plans to spend that

Sanofi has reaped $11.1 billion after selling off a big chunk of its Regeneron stock at $515 a share. And now everyone on the M&A side of the business is focused on how CEO Paul Hudson plans to spend it.

After getting stung in France for some awkward politicking — suggesting the US was in the front of the line for Sanofi’s vaccines given American financial support for their work, versus little help from European powers — Hudson now has the much more popular task of managing a major cash cache to pull off something in the order of a big bolt-on. Or two.

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Ab­b­Vie wins an ap­proval in uter­ine fi­broid-as­so­ci­at­ed heavy bleed­ing. Are ri­vals My­ovant and Ob­sE­va far be­hind?

Women expel on average about 2 to 3 tablespoons of blood during their time of the month. But with uterine fibroids, heavy bleeding is typical — a third of a cup or more. Drugmakers have been working on oral therapies to try and stem the flow, and as expected, AbbVie and their partners at Neurocrine Biosciences are the first to make it across the finish line.

Known chemically as elagolix, the drug is already approved as a treatment for endometriosis under the brand name Orilissa. It targets the GnRH receptor to decrease the production of estrogen and progesterone.

David Chang, Allogene CEO (Jeff Rumans)

Head­ed to PhII: Al­lo­gene CEO David Chang com­pletes a pos­i­tive ear­ly snap­shot of their off-the-shelf CAR-T pi­o­neer

Allogene CEO David Chang has completed the upbeat first portrait of the biotech’s off-the-shelf CAR-T contender ALLO-501 at virtual ASCO today, keeping all eyes on a drug that will now try to go on to replace the first-wave personalized pioneers he helped create.

The overall response rate outlined in Allogene’s abstract for treatment-resistant patients with non-Hodgkin lymphoma slipped a little from the leadup, but if you narrow the patient profile to treatment-naïve patients — removing the 3 who had previous CAR-T therapy who didn’t respond, leaving 16 — the ORR lands at 75% with a 44% complete response rate. And 9 of the 12 responders remained in response at the data cutoff, offering a glimpse on durability that still has a long way to go before it can be completely nailed down.

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Roger Perlmutter, Merck R&D chief (YouTube)

Backed by BAR­DA, Mer­ck jumps in­to Covid-19: buy­ing out a vac­cine, part­ner­ing on an­oth­er and adding an­tivi­ral to the mix

Merck execs are making a triple play in a sudden leap into the R&D campaign against Covid-19. And they have more BARDA cash backing them up on the move.

Tuesday morning the pharma giant simultaneously announced plans to buy an Austrian biotech that has been working on a preclinical vaccine candidate, added a collaboration on another vaccine with the nonprofit IAVI and inked a deal with Ridgeback Biotherapeutics on an early-stage antiviral.

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As­traZeneca’s $7B ADC suc­ceeds where Roche failed, im­prov­ing sur­vival in gas­tric can­cer

Another day, another win for Enhertu.

The antibody-drug conjugate AstraZeneca promised up-to $7 billion to partner on has had a quite a few months, beginning with splashy results in a Phase II breast cancer trial, a rapid approval and, earlier this month, breakthrough designations in both non-small cell lung cancer and gastric cancer.

Now, at ASCO, the British pharma and their Japanese partner, Daiichi Sankyo, have shown off the data that led to the gastric cancer designation, which they’ll take back to the FDA. In a pivotal, 187-person Phase II trial, Enhertu shrunk tumors in 42.9% of third-line patients with HER2-positive stomach cancer, compared with 12.5% in a control arm where doctors prescribed their choice of therapy. Progression-free survival was 5.4 months for Enhertu compared to 3.5 months for the control.