Cellectis, rising star Allogene design an 'all-in-one' CAR construct with embedded safety switch as the new partners angle for the clinic
When Arie Belldegrun and David Chang bagged all of Pfizer’s off-the-shelf CAR-T therapies, they highlighted a collaboration program with Cellectis that potentially puts Allogene Therapeutics on a path to commercialization. Two months later, the French biotech is following up with a safer, next-generation chimeric antigen receptor construct now positioned for the clinic.
In a paper published in Scientific Reports today, Cellectis reports an all-in-one CAR architecture that combines cancer-killing potency, a “suicide switch” for safety, as well as purification and detection capacities. Dubbed CubiCAR, the molecule was shown to be “efficiently and robustly” depleted in the presence of Rituxan (rituximab) both in vitro and in vivo.
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