Chi­nese in­vestors back Refuge Bio’s $25M B round as it steers gene en­gi­neer­ing tech to an IND

A group of Chi­nese in­vestors led by 3SBio and Se­quoia Chi­na are bankrolling the next leg of de­vel­op­ment at Refuge Biotech­nolo­gies, a Bay Area biotech that’s been us­ing CRISPR tech­nol­o­gy to con­trol gene ex­pres­sion.

The syn­di­cate is pro­vid­ing $25 mil­lion in a Se­ries B as Refuge fine tunes a tech­nol­o­gy ini­tial­ly de­vel­oped in the lab of Stan­ley Qi at Stan­ford. Qi mu­tat­ed the Cas9 pro­tein so it couldn’t do the cut­ting used in gene edit­ing. That way it can be used to de­liv­er a tran­scrip­tion­al ac­ti­va­tor or re­pres­sor to turn a gene off or on.

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