Chi­nese start­up with Mer­ck vet at the helm ac­quires rights to Oys­ter Point's eye dis­ease nasal spray

With the Chi­nese drug mar­ket start­ing to bear fruit, West­ern drug­mak­ers have looked to wig­gle their way in, of­ten lean­ing on lo­cal part­ners to do the grunt work on the ground. With so many Chi­nese com­pa­nies play­ing the will­ing host, a fledg­ling start­up with a Mer­ck vet­er­an lead­ing the way will now take on an­oth­er West­ern part­ner of its own.

Ji Xing Phar­ma­ceu­ti­cals has ac­quired the Greater Chi­nese rights to Oys­ter Point Phar­ma’s nasal spray for dry eye dis­ease can­di­dates OC-01 and OC-02 in ex­change for $17.5 mil­lion in up­front cash and 0.75% eq­ui­ty in the emerg­ing Chi­nese biotech, the part­ners said Thurs­day.

The deal comes with $204.8 mil­lion in biobucks and serves as the sec­ond West­ern part­ner­ship for Ji Xing, an RTW In­vest­ments-backed com­pa­ny head­quar­tered in Shang­hai that emerged from stealth last month with an undis­closed B round in hand.

Joe Ro­manel­li

The firm is helmed by Joe Ro­manel­li, the for­mer pres­i­dent of Mer­ck Chi­na who over­saw the launch of 20 prod­ucts in that re­gion, in­clud­ing I/O su­per­star Keytru­da and HPV vac­cine Gar­dasil, which the biotech said was the biggest drug by rev­enue in Chi­na pro­duced by a multi­na­tion­al.

Dur­ing his four-year tenure with the New Jer­sey drug­mak­er, Ro­manel­li over­saw its evo­lu­tion from the sev­enth-largest multi­na­tion­al drug­mak­er op­er­at­ing in Chi­na to the sec­ond by the time he jumped ship.

“Stim­u­lat­ing nat­ur­al tear film pro­duc­tion may be a par­a­digm-chang­ing way to treat dry eye dis­ease, which af­fects more than 150 mil­lion pa­tients in Chi­na,” Ro­manel­li said about the Oys­ter Point deal. “We are ex­cit­ed to part­ner with the Oys­ter Point team, who are in­no­v­a­tive pi­o­neers fo­cused on de­vel­op­ing ther­a­peu­tics for oph­thalmic dis­eases, and bring both OC-01 and OC-02 to Chi­na.”

Ji Xing’s oth­er West­ern part­ner­ship, a li­cens­ing deal with Mile­stone Phar­ma­ceu­ti­cals, is al­so for a nasal spray, this time for parox­ys­mal supraven­tric­u­lar tachy­car­dia and oth­er car­dio­vas­cu­lar in­di­ca­tions. The drug, dubbed etri­pamil, is cur­rent­ly in Phase III test­ing.

Lina Gugucheva, NewAmsterdam Pharma CBO

Phar­ma group bets up to $1B-plus on the PhI­II res­ur­rec­tion of a once dead-and-buried LDL drug

Close to 5 years after then-Amgen R&D chief Sean Harper tamped the last spade of dirt on the last broadly focused CETP cholesterol drug — burying their $300 million upfront and the few remaining hopes for the class with it — the therapy has been fully resurrected. And today, the NewAmsterdam Pharma crew that did the Lazarus treatment on obicetrapib is taking another big step on the comeback trail with a €1 billion-plus regional licensing deal, complete with close to $150 million in upfront cash.

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Scoop: Boehringer qui­et­ly shut­ters a PhII for one of its top drugs — now un­der re­view

Boehringer Ingelheim has quietly shut down a small Phase II study for one of its lead drugs.

The private pharma player confirmed to Endpoints News that it had shuttered a study testing spesolimab as a therapy for Crohn’s patients suffering from bowel obstructions.

A spokesperson for the company tells Endpoints:

Taking into consideration the current therapeutic landscape and ongoing clinical development programs, Boehringer Ingelheim decided to discontinue our program in Crohn’s disease. It is important to note that this decision is not based on any safety findings in the clinical trials.

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Vas Narasimhan (Photographer: Jason Alden/Bloomberg via Getty Images)

No­var­tis de­tails plans to axe 8,000 staffers as Narasimhan be­gins sec­ond phase of a glob­al re­org

We now know the number of jobs coming under the axe at Novartis, and it isn’t small.

The pharma giant is confirming a report from Swiss newspaper Tages-Anzeiger that it is chopping 8,000 jobs out of its 108,000 global staffers. A large segment will hit right at company headquarters in Basel, as CEO Vas Narasimhan axes some 1,400 of a little more than 11,000  jobs in Switzerland.

The first phase of the work is almost done, the company says in a statement to Endpoints News. Now it’s on to phase two. In the statement, Novartis says:

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How pre­pared is bio­phar­ma for the cy­ber dooms­day?

One of the largest cyberattacks in history happened on a Friday, Eric Perakslis distinctly remembers.

Perakslis, who was head of Takeda’s R&D Data Sciences Institute and visiting faculty at Harvard Medical School at the time, had spent that morning completing a review on cybersecurity for the British Medical Journal. Moments after he turned it in, he heard back from the editor: “Have you heard what’s going on right now?”

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(AP Photo/Gemunu Amarasinghe)

Some phar­ma com­pa­nies promise to cov­er abor­tion-re­lat­ed trav­el costs — while oth­ers won't go that far yet

As the US Department of Health and Human Services promises to support the millions of women who would now need to cross state lines to receive a legal abortion, a handful of pharma companies have said they will pick up employees’ travel expenses.

GSK, Sanofi, Johnson & Johnson, BeiGene, Alnylam and Gilead have all committed to covering abortion-related travel expenses just four days after the Supreme Court overturned Roe v. Wade and revoked women’s constitutional right to an abortion.

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Aurobindo Pharma co-founders P. V. Ram Prasad Reddy (L) and K. Nityananda Reddy

Au­robindo Phar­ma re­ceives warn­ing let­ter from In­di­a's SEC fol­low­ing more FDA ques­tion marks

Indian-based generics manufacturer Aurobindo Pharma has been in the crosshairs of the FDA for several years now, but the company is also attracting attention from regulators within the subcontinent.

According to the Indian business news site Business Standard, a warning letter was sent to the company from the Securities Exchange Board of India, or SEBI.

The letter is related to disclosures made by the company on an ongoing FDA audit of the company’s Unit-1 API facility in Hyderabad, India as well as observations made by the US regulator between 2019 and 2022.

New Charles River Laboratories High Quality (HQ) Plasmid DNA Centre of Excellence at Bruntwood SciTech’s Alderley Park in Cheshire, United Kingdom. (Charles River)

Charles Riv­er Lab­o­ra­to­ries to start cell and gene ther­a­py man­u­fac­tur­ing at UK site in Sep­tem­ber

While Massachusetts-based Charles River Laboratories has been on an acquisition spree, they are not against planting their flag. The latest move by the company sees them crossing the pond to establish a manufacturing site in the UK.

The company on Tuesday opened its cell and gene therapy manufacturing center at Bruntwood SciTech’s Alderley Park in Cheshire, United Kingdom. The expansion follows Charles River’s acquisition of Cognate BioServices and Cobra Biologics in 2021 for $875 million. Cognate is a plasmid DNA, viral vector and cell therapy CDMO.

Bristol Myers Squibb (Alamy)

CVS re­sumes cov­er­age of block­buster blood thin­ner af­ter price drop fol­lows Jan­u­ary ex­clu­sion

Following some backlash from the American College of Cardiology and patients, Bristol Myers Squibb and Pfizer lowered the price of their blockbuster blood thinner Eliquis, thus ensuring that CVS Caremark would cover the drug after 6 months of it being off the major PBM’s formulary.

“Because we secured lower net costs for patients from negotiations with the drug manufacturer, Eliquis will be added back to our template formularies for the commercial segment effective July 1, 2022, and patient choices will be expanded,” CVS Health said in an emailed statement. “Anti-coagulant therapies are among the non-specialty products where we are seeing the fastest cost increases from drug manufacturers and we will continue to push back on unwarranted price increases.”

#Can­nes­Lions2022: Con­sumer health ex­ecs call on agen­cies to in­volve pa­tients in cre­ative process

CANNES — When Tamara Rogers joined GSK back in 2018, “science was king and R&D were the gods.” Now the global chief marketing officer of consumer healthcare wants to make room for another supreme being: the consumer.

As health and wellness becomes more relevant to consumers amid the pandemic, four health-focused executives called on marketers to involve patients in their creative process in a panel discussion at the Cannes Lions advertising creativity festival.

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