CymaBay shares get a bounce on pos­i­tive PBC PhII da­ta

CymaBay Ther­a­peu­tics got a bad­ly need­ed boost this morn­ing af­ter its lead drug scored some pos­i­tive da­ta in a Phase II tri­al.

The Newark, CA-based biotech — the old Metabolex, which has had its share of ups and downs over the years — says two dos­es of saledel­par demon­strat­ed an abil­i­ty to slash lev­els of al­ka­line phos­phatase among treat­ment-re­sis­tant pa­tients suf­fer­ing from pri­ma­ry bil­iary cholan­gi­tis. The 5 mg and 10 mg dos­es cut AP lev­els by 39% and 45% from base­line af­ter 12 weeks of ther­a­py.

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