Elan­co to buy Bay­er's an­i­mal health busi­ness for $7.6B, as deal­mak­ing gath­ers steam in the sec­tor

Last week, Elan­co ex­plic­it­ly dodged an­swer­ing ques­tions about its ru­mored in­ter­est in Bay­er’s ani­mal health busi­ness in its post-earn­ings call. On Tues­day, the Eli Lil­ly spin­off dis­closed it was pur­chas­ing the Ger­man drug mak­er’s vet­eri­nary unit in a cash-and-stock deal worth $7.6 bil­lion

Elan­co $ELAN has been busy on the deal-mak­ing front. In April, it laid out plans to swal­low its part­ner, Kansas-based pet ther­a­peu­tics com­pa­ny Aratana $PETX. A Ju­ly re­port by Reuters sug­gest­ed a po­ten­tial Bay­er deal was be­ing ex­plored, and Bloomberg last week said the deal was im­mi­nent, cit­ing sources. 

Deal mak­ing with­in the AH space is par­tic­u­lar­ly at­trac­tive — ver­sus the field of hu­man health­care — prod­uct port­fo­lios are more sus­tain­able, ex­po­sure to gener­ic threats is lim­it­ed, and there is es­sen­tial­ly no di­rect ex­po­sure to pay­or re­im­burse­ment cuts.

When the Elan­co/Bay­er ru­mors were swirling, Cred­it Su­isse’s Erin Wright an­a­lyzed the ra­tio­nale be­hind the deal in a note ear­li­er this month.

“The the­o­rized deal rep­re­sents a mean­ing­ful de­par­ture from the pre­vi­ous the­sis for ELAN, which was large­ly pred­i­cat­ed on its mean­ing­ful mar­gin ex­pan­sion sto­ry (~1,000 bps by 2023) and in­no­va­tion ef­forts, where it boasts >100 R&D pro­grams with 36 nov­el “shots on goal” over the next 5 years, with al­so sup­port from re­cent (PETX) and oth­er M&A/part­ner­ships, lever­ag­ing its flex­i­bil­i­ty as a stand­alone en­ti­ty,” she wrote. “The scale of the deal is al­so clear­ly sur­pris­ing…giv­en BAH’s mea­ger growth tra­jec­to­ry, un­less there are hid­den gems in its R&D pipeline, we aren’t en­tire­ly sure how this will ad­vance ELAN as a stand­alone en­ti­ty.”

Bay­er is un­der pres­sure to raise cash and lift its mar­ket val­ue fol­low­ing its $63 bil­lion pur­chase of agro­chem­i­cal com­pa­ny Mon­san­to. Last No­vem­ber, the Ger­man drug gi­ant an­nounced it was plan­ning to ex­it the an­i­mal health busi­ness, which is skewed to­wards com­pan­ion an­i­mal (60%) ver­sus live­stock (40%), rel­a­tive to its peers.

“While it boasts a port­fo­lio of >100 prod­ucts and pres­ence across 120 coun­tries (3,500 em­ploy­ees glob­al­ly), it has dis­pro­por­tion­ate ex­po­sure to key prod­ucts, with 62% of sales de­rived from four prod­uct lines, rep­re­sent­ing a rel­a­tive­ly con­cen­trat­ed port­fo­lio,” Wright not­ed.

Un­der the terms of the deal, Bay­er will get $5.32 bil­lion in cash and rough­ly 68 mil­lion Elan­co An­i­mal Health com­mon shares. The deal is set to ex­pand Elan­co’s ar­se­nal of prod­ucts, in­clud­ing the ad­di­tion of par­a­siti­cides (top­i­cal treat­ments, col­lars), en­able com­pan­ion health to ac­count for half of its busi­ness, and aug­ment its R&D pipeline.

The trans­ac­tion, which is ex­pect­ed to close in mid-2020, will cre­ate the sec­ond-largest an­i­mal health com­pa­ny in the field, Elan­co said. Last year, Elan­co gen­er­at­ed sales of about $3.1 bil­lion, while Bay­er’s AH unit raked in about $1.6 bil­lion. The lead­ing firm in the sec­tor — Zoetis — brought in rough­ly $5.8 bil­lion in 2018 sales.

The an­i­mal health space is ripe for con­sol­i­da­tion, and M&A will con­tin­ue — as in­dus­try play­ers look to ex­pand their mar­ket share across ge­o­gra­phies and in “tan­gen­tial busi­ness­es to low­er ex­po­sure to any one re­gion, prod­uct line, or species,” Wright added on Tues­day.

The Big Phar­ma dis­card pile; Lay­offs all around while some biotechs bid farewell; New Roche CEO as­sem­bles top team; and more

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With earnings seasons in full swing, we’ve listened in on all the calls so you don’t have to. But news is popping up from all corners, so make sure you check out our other updates, too.

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Trodelvy notch­es a win in most com­mon form of breast can­cer

Following a promise last year to go “big and fast in breast cancer,” Gilead has secured a win for Trodelvy in the most common form.

The drug was approved to treat HR-positive, HER2-negative breast cancer patients who’ve already received endocrine-based therapy and at least two other systemic therapies for metastatic cancer, Gilead announced on Friday.

Trodelvy won its first indication in metastatic triple-negative breast cancer back in 2020, and has since added urothelial cancer to the list. HR-positive HER2-negative breast cancer accounts for roughly 70% of new breast cancer cases worldwide per year, according to senior VP of oncology clinical development Bill Grossman, and many patients develop resistance to endocrine-based therapies or worsen on chemotherapy.

Sen. Ron Wyden (D-OR) (Francis Chung/E&E News/Politico via AP Images)

In­fla­tion re­bates in­com­ing: Wyden calls on CMS to move quick­ly as No­var­tis CEO pledges re­ver­sal

Senate Finance Chair Ron Wyden (D-OR) this week sent a letter to the head of the Centers for Medicare & Medicaid Services seeking an update on how and when new inflation-linked rebates will take effect for drugs that see major price spikes.

The newly signed Inflation Reduction Act requires manufacturers to pay a rebate to Medicare when they increase drug prices faster than the rate of inflation.

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Te­va drops out of in­dus­try trade group PhRMA

Following in AbbVie’s footsteps, Teva confirmed on Friday that it’s dropping out of the industry trade group Pharmaceutical Research and Manufacturers of America (PhRMA).

Teva didn’t give a reason for its decision to leave, saying only in a statement to Endpoints News that it annually reviews “effectiveness and value of engagements, consultants and memberships to ensure our investments are properly seated.”

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Sanofi CFO Jean-Baptiste de Chatillon (L) and CEO Paul Hudson (Romuald Meigneux/Sipa via AP Images)

Sanofi sees downtick in flu sales as it preps for launch of RSV an­ti­body

Sanofi expects its RSV antibody jointly developed with AstraZeneca will be available next season, executive VP of vaccines Thomas Triomphe announced on the company’s quarterly call.

Beyfortus, also known as nirsevimab, was approved in the EU back in November and is currently under FDA review with an expected decision coming in the third quarter of this year. The news comes as the FDA plans to hold advisory committee meetings over the next couple months to review RSV vaccines from Pfizer and GSK.

Christophe Weber, Takeda CEO (Photographer: Shoko Takayasu/Bloomberg via Getty Images)

Take­da fo­cus­es on ‘di­verse’ pipeline prospects on heels of two ac­qui­si­tions

After a whopping $4 billion asset buy from Nimbus Therapeutics, along with a $400 million deal with Hutchmed for a colorectal cancer drug, Takeda executives touted pipeline optimism on its latest earnings call this week.

That’s because the TYK2 inhibitor for psoriasis Takeda is getting from Nimbus, along with the Hutchmed fruquintinib commercialization outside of China, are just two of what it reports are 10 late-stage development programs of promising candidates.

Regeneron CSO George Yancopoulos (L) and CEO Len Schleifer at a groundbreaking for its new Tarrytown, NY facility, June 2022 (Lev Radin/Pacific Press/LightRocket via Getty Images)

In show­down with Roche, Re­gen­eron gears up for po­ten­tial Eylea ex­pan­sion amid Covid de­cline

Regeneron faced a substantial slump in overall revenue last year, but the focus still remains on some of its biggest blockbusters.

The pharma with several high-profile partnerships — Sanofi and Bayer among them — said Friday that Q4 revenue was down 31% for the quarter, and down 24% for the entire year. However, that won’t stop blockbuster expansion plans.

One of those is Eylea, the Bayer-partnered eye disease drug that has been in major competition with Roche’s Vabysmo. While Eylea is currently only approved in a 2 mg dose, the company recently filed for approval to give a 8 mg dose, in hopes of making a longer-lasting treatment.

BeiGene's new website helps direct cancer patients and caregivers to a wide variety of sources for help.

BeiGene re­veals men­tal health and can­cer care gap in study, de­buts dig­i­tal re­sources

One-fourth of cancer patients are living with depression — and another 20% suffer from anxiety. That’s according to new study results from BeiGene, conducted by Cancer Support Community (CSC), about the mental and emotional health of cancer patients.

While the fact that people with cancer are also dealing with depression or anxiety may not be surprising, what is — and was to BeiGene — is that a majority of them aren’t getting support. 60% of respondents said they were not referred to a mental health professional, and even more concerning, two in five who specifically asked for mental health help did not get it. CSC, a nonprofit mental health in cancer advocacy group, surveyed more than 600 US cancer patients.

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One of the paintings from Gilead's latest campaign making AI art to help MBC patients be 'seen and heard.'

Gilead com­bines ar­ti­fi­cial in­tel­li­gence and art to draw at­ten­tion and hope to MBC

What if you could “see” the emotions and feelings of people living with metastatic breast cancer? That’s what Gilead Sciences’ agency VMLY&R Health did last year, using artificial intelligence and sound analytics to turn the interviews of three women living with metastatic triple-negative breast cancer into works of art.

Using the sound waves, a robotic painting device translated their stories of struggle and hope into colors, contours and brush strokes. The result? An art exhibition called “Paintings of Hope” that was first displayed at ESMO in September in Paris, but has since traveled to hospitals and medical conferences in Europe and Spain.

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