Eli Lil­ly R&D chief Jan Lund­berg heads for the ex­it as CEO as­sem­bles a new team at the top

A day af­ter the FDA ap­proved abe­maci­clib, new Eli Lil­ly CEO Dave Ricks has tapped sev­er­al new chiefs for the phar­ma gi­ant’s ex­ec­u­tive com­mit­tee. And the change-out in­cludes the de­par­ture of R&D chief Jan Lund­berg as Ricks pro­motes Dan Skovron­sky as the new head of sci­ence and tech­nol­o­gy and pres­i­dent of Lil­ly Re­search Labs.

Lund­berg has been a cen­tral fig­ure at Lil­ly over the last 8 years, a cru­cial pe­ri­od that saw out the end of John Lech­leit­er’s ca­reer at the top and the be­gin­ning of a stream of new drug ap­provals that are cen­tral to its longterm suc­cess. It hasn’t al­ways been pret­ty, but the R&D group has kept its eyes on chang­ing stan­dards of care in can­cer, di­a­betes and oth­er dis­eases that have seen some big de­vel­op­ments in the re­cent past.

Dan Skovron­sky

The ques­tion now is whether Lund­berg — who al­so led dis­cov­ery re­search at As­traZeneca be­fore mak­ing the leap to Lil­ly — will ac­tu­al­ly go ahead and re­tire or sim­ply jump to a new job af­ter a de­cent in­ter­val, a path fol­lowed by a grow­ing num­ber of se­nior ex­ecs who have found new ca­reers in the com­fort­ing arms of a boom­ing VC com­mu­ni­ty.

Skovron­sky — most re­cent­ly the de­vel­op­ment chief at Lil­ly — joined the com­pa­ny back in 2010, when Lech­leit­er bought out Avid Ra­dio­phar­ma­ceu­ti­cals in or­der to get its hands on a brain-imag­ing tech­nol­o­gy that could high­light be­ta-amy­loid in the brain. Lil­ly has spent years and a for­tune pur­su­ing new ways to al­ter the tra­jec­to­ry of Alzheimer’s, with noth­ing to show for it so far.

The com­pa­ny has had much bet­ter suc­cess with can­cer, as it demon­strat­ed yes­ter­day with the ap­proval of abe­maci­clib, a CDK 4/6 drug which will now go head to head with two ma­jor league ri­vals al­ready on the mar­ket. Lil­ly says the drug will be sold as Verzenio.

Eli Lil­ly has made a shift­ing set of promis­es on the R&D front, with­out ac­tu­al­ly de­liv­er­ing right on sched­ule. One of the lat­est up­dates on that score in­clud­ed a promise of 20 new drugs ap­provals in a decade run stretch­ing from 2014 to 2023. Ricks al­so has been chang­ing up the pipeline fo­cus some­what, while cut­ting in­to the staff in a move to re­duce costs by elim­i­nat­ing 8.5% of its em­ploy­ee ros­ter.

There are sev­er­al oth­er new se­nior ex­ec an­nounce­ments to­day, in­clud­ing:

— The pro­mo­tion of Josh Smi­ley to se­nior vice pres­i­dent and chief fi­nan­cial of­fi­cer.

— Myles O’Neill is tak­ing over the lead role in man­u­fac­tur­ing.

— Aar­ti Shah, SVP and chief of in­for­ma­tion tech, is be­ing bumped up a lev­el to EVP.


The Eli Lil­ly and Co cor­po­rate head­quar­ters is pic­tured April 26, 2017, in In­di­anapo­lis. AP Pho­to

Dan Skovronsky, Eli Lilly CSO

UP­DAT­ED: An­a­lysts are quick to pan Eli Lil­ly's puz­zling first cut of pos­i­tive clin­i­cal da­ta for its Covid-19 an­ti­body

Eli Lilly spotlighted a success for one of 3 doses of their closely-watched Covid-19 antibody drug Wednesday morning. But analysts quickly highlighted some obvious anomalies that could come back to haunt the pharma giant as it looks for an emergency use authorization to launch marketing efforts.

The pharma giant reported that LY-CoV555, developed in collaboration with AbCellera, significantly reduced the rate of hospitalization among patients who were treated with the antibody. The drug arm of the study had a 1.7% hospitalization rate, compared to 6% in the control group, marking a 72% drop in risk.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 90,300+ biopharma pros reading Endpoints daily — and it's free.

#ES­MO20: Alk­er­mes of­fers their first snap­shot of a ben­e­fit for their next-gen IL-2 drug. But why did 1 pa­tient starve to death?

Everyone in the cancer R&D arena is looking to build new franchises around better drugs and combos. And one busy pocket of that space is centered entirely on creating an IL-2 drug that can be as effective as the original without the toxicity that damned it to the sidelines.

Alkermes $ALKS formally tossed its hat into the ring of contenders at virtual ESMO today, highlighting the first glimpse of efficacy for their candidate, ALKS 4230, as both a monotherapy as well as in combination with Merck’s Keytruda.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 90,300+ biopharma pros reading Endpoints daily — and it's free.

Albert Bourla, Pfizer CEO (Steven Ferdman/Getty Images)

Pfiz­er ex­ecs con­fi­dent­ly tap their top 10 block­busters-to-be. But what are the chances of sur­viv­ing PhI­II, let alone hit­ting these big peak sales es­ti­mates?

Pfizer’s top executive team doesn’t lack for confidence.

Where many Big Pharmas would be reluctant to put a peak sales figure on their late-stage drugs, Pfizer CEO Albert Bourla has shrugged off the usual diffidence to outline where the pharma giant expects to get $15 billion-plus.

The list, outlined this week during their investor presentations, is topped by 3 drugs in the $3 billion-plus peak sales category. They are:

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 90,300+ biopharma pros reading Endpoints daily — and it's free.

Seat­tle Ge­net­ic­s' Astel­las-part­nered ADC nails con­fir­ma­to­ry PhI­II in urothe­lial can­cer

Nine months after Seattle Genetics nabbed an accelerated approval for its Astellas-partnered antibody-drug conjugate Padcev, the partners said the therapy has nailed a confirmatory Phase III, proving its worth in locally advanced or metastatic urothelial cancer.

Padcev, which has widely been tapped as a potential blockbuster, scored improvements in both overall survival and progression-free survival compared to chemotherapy, causing a 30% reduction in risk of death (p = 0.001) and 39% reduction in risk of disease progression or death (p<0.00001).

Albert Bourla (Photo by Steven Ferdman/Getty Images)

Pfiz­er match­es Mod­er­na with their full Covid-19 tri­al blue­print — As­traZeneca says it will un­veil its pro­to­col 'short­ly'

Yesterday, after sustained public pressure as Moderna released its Phase III Covid-19 trial blueprint, Pfizer released its own full trial design for their vaccine trials. The move was designed to boost transparency and shore up public trust in the vaccines, but it also revealed differences in how the two companies are approaching the much-watched studies while failing to satisfy the demands of the fiercest advocates for transparency.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 90,300+ biopharma pros reading Endpoints daily — and it's free.

#ES­MO20: Re­gen­eron, Sanofi eye an­oth­er first for their PD-1 con­tender Lib­tayo with promis­ing da­ta for on­col­o­gy niche

Regeneron and Sanofi took another step forward in the long march towards a greatly expanded market for their late-bloomer PD-1 checkpoint Libtayo.

The two occasional allies posted an objective response rate of 31% for Libtayo among 84 patients suffering from advanced cases of basal cell carcinoma at virtual ESMO. That spotlights progress for 26 patients, 5 of whom had a complete response. The data also reflect a boost in the number of responses seen from the last cut of the numbers.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 90,300+ biopharma pros reading Endpoints daily — and it's free.

Christian Itin, Autolus CEO (Autolus)

#ES­MO20: Au­to­lus pro­vides glimpse of next-gen­er­a­tion CAR-T pro­gram, show­ing ear­ly pos­i­tive safe­ty da­ta

CAR-T therapies were hailed as a breakthrough when Novartis received the first FDA approval for Kymriah back in 2017. Though highly effective at treating certain types of blood cancers, CAR-Ts are also associated with severe and potentially deadly side effects, including lethal instances of cytokine release syndrome.

With this in mind, Autolus Therapeutics is looking to take a crack at a safer CAR-T and presented Phase II cohort data for its AUTO3 program at virtual ESMO 2020. The data showed that, among the 35 patients in the cohort being treated for r/r diffuse large B cell lymphoma, there were no instances of Grade 3 or higher CRS. Eight individuals saw Grade 1 inflammation while another four patients reached Grade 2.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 90,300+ biopharma pros reading Endpoints daily — and it's free.

Rep. Andy Harris (R-MD) (Tasos Katopodis/Pool via AP Images)

UP­DAT­ED: A mi­cro-cap with a po­ten­tial­ly promis­ing coro­n­avirus drug en­lists mask-skep­tic con­gress­man for DSMB

A small biotech that has talked up a potentially promising but unproven treatment for Covid-19 enlisted an unusual member for its study’s Data and Safety Monitoring Board: a sitting Republican congressman with close ties to the CEO and a history of mask skepticism.

NeuroRx, an Israeli biotech testing a lung inflammation drug in Covid-19 patients, tapped Maryland Rep. Andy Harris for the DSMB, Politico reported. Harris is an anesthesiologist but not a biostatistician, and he has questioned the CDC about a “cult of masks” in the US. Harris has known NeuroRx CEO Jonathan Javitt since the two worked at Johns Hopkins together over 20 years ago.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 90,300+ biopharma pros reading Endpoints daily — and it's free.

Stronger to­geth­er? Boehringer and Mi­rati team to put first KRAS-KRAS com­bo in the clin­ic

Researchers are still waiting to see how much any of the vaunted KRAS drugs now in the clinic can, after decades of preclinical research and some early human studies, help patients. But while they do, two of the leading developers will look to see whether a KRAS-KRAS combo might pose a better shot than any KRAS alone.

Boehringer Ingelheim and Mirati have signed a collaboration to combine Mirati’s closely-watched lead KRAS inhibitor, MRTX849, in a clinical trial with the pan-KRAS blocker that Boehringer has quietly developed with high expectations behind their flashier contenders.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 90,300+ biopharma pros reading Endpoints daily — and it's free.