Ex-Al­ler­gan CMO takes the helm at Lewis Cant­ley's metas­ta­sis-fo­cused biotech start­up

Al­ler­gan’s for­mer top team is mov­ing on­to new ad­ven­tures as Ab­b­Vie ex­ecs take di­rect con­trol of their shop.

Just days af­ter Brent Saun­ders pitched a $460 mil­lion SPAC for his next big move, his chief med­ical of­fi­cer is tak­ing up the CEO post at a biotech start­up out of New York.

Charles Hugh-Jones

For Charles Hugh-Jones, the role at Volas­tra Ther­a­peu­tics brings him back to a nar­row fo­cus on on­col­o­gy, an area he’s spe­cial­ized in through­out his years at Scher­ing/Bay­er, Sanofi, and even­tu­al­ly Pfiz­er. But in­stead of over­see­ing late-stage de­vel­op­ment, he is fac­ing the chal­lenge of bring­ing some ear­ly-stage drug can­di­dates for­ward.

Found­ed by Cor­nell’s Lewis Cant­ley — famed for dis­cov­er­ing the PI3K path­way’s role in can­cer — as well as Olivi­er El­e­men­to and Samuel Bakhoum at Memo­r­i­al Sloan Ket­ter­ing, Volas­tra set out to tack­le chro­mo­so­mal in­sta­bil­i­ty, which Cant­ley calls “a per­va­sive fea­ture of metasta­t­ic can­cers.”

While work­ing at Cant­ley’s lab, Bakhoum elu­ci­dat­ed that lag­ging chro­mo­somes trig­ger a mi­gra­tion of white blood cells to var­i­ous in­flam­ma­tion spots — mi­gra­tion that can­cer cells can ride on to spread across the body.

Lewis Cant­ley

“We can take a cell that’s chro­mo­so­ma­l­ly un­sta­ble and fix it so chro­mo­somes won’t lag be­hind,” Cant­ley, who has two oth­er star­tups (Agios and Pe­tra Phar­ma) un­der his belt, pre­vi­ous­ly told End­points News. “And those cells will not metas­ta­size.”

Metasta­t­ic sol­id tu­mors are no­to­ri­ous­ly among the tough­est to treat, Hugh-Jones not­ed. The mis­sion of fo­cus­ing ex­clu­sive on “defin­ing and treat­ing the bi­ol­o­gy of metas­ta­sis” —the cause of death in 90% of can­cer pa­tients — was a big rea­son he was drawn to the com­pa­ny af­ter get­ting con­nect­ed ear­ly in 2020.

With $20 mil­lion from Po­laris Part­ners, Vi­da Ven­tures, ARCH and oth­er VCs, Volas­tra has se­cured space in West Harlem to house its grow­ing team.

Secretary of health and human services Alex Azar speaking in the Rose Garden at the White House (Photo: AFP)

Trump’s HHS claims ab­solute au­thor­i­ty over the FDA, clear­ing path to a vac­cine EUA

The top career staff at the FDA has vowed not to let politics overrule science when looking at vaccine data this fall. But Alex Azar, who happens to be their boss’s boss, apparently won’t even give them a chance to stand in the way.

In a new memorandum issued Tuesday last week, the HHS chief stripped the FDA and other health agencies under his purview of their rule making ability, asserting all such power “is reserved to the Secretary.” Sheila Kaplan of the New York Times first obtained and reported the details of the September 15 bulletin.

Anthony Fauci (AP Images)

A press of­fi­cer at An­tho­ny Fau­ci’s NI­AID was un­masked as a hard-right Covid troll. He just re­tired to­day

William B Crews had been a public affairs specialist at the NIH’s National Institute of Allergy and Infectious Diseases.

That ended today when he informed the agency of his decision to retire, after he was identified as the managing editor at RedState, a prominent Trump loyalist website.

Crews’ RedState duties are performed under the alias streiff. While enjoying the benefits of pseudonymity, he disparaged and worked against NIAID with an incendiary level of rhetoric in the midst of a pandemic.

#ES­MO20: Push­ing in­to front­line, Mer­ck and Bris­tol My­ers duke it out with new slate of GI can­cer da­ta

Having worked in parallel for years to move their respective PD-1 inhibitors up to the first-line treatment of gastrointestinal cancers, Merck and Bristol Myers Squibb finally have the data at ESMO for a showdown.

Comparing KEYNOTE-590 and CheckMate-649, of course, comes with the usual caveats. But a side-by-side look at the overall survival numbers also offer some perspective on a new frontier for the reigning checkpoint rivals, both of whom are claiming to have achieved a first.

Frank Zhang (AP Images)

Rocked by cus­toms in­ves­ti­ga­tion, Leg­end's CFO takes over as CEO Frank Zhang placed un­der house ar­rest

When Frank Zhang stepped down from GenScript — the contract research group he’s run for 18 years — to take up the CEO post at its CAR-T focused spinout Legend Biotech, he assured analysts that he was in for the long haul.

Just 49 days later, though, he’s been forced to hand back the title.

In a dramatic turn of events, Legend disclosed that Zhang is under house arrest in China as part of a customs investigation involving GenScript. While he remains the chairman, CFO Ying Huang has been tapped to double as interim CEO.

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UP­DAT­ED: Two wild weeks for Grail end in $8B Il­lu­mi­na buy­out

Grail’s whirlwind two weeks have ended in the wealthy arms of its former founder and benefactors.

Illumina has shelled out $8 billion to reacquire the closely-watched liquid biopsy startup they spun out just 5 years ago and sold off much of its shares just 3 years ago. The deal comes nearly two weeks after the well-heeled startup filed for a potentially massive IPO — one that was disrupted just a week later when Bloomberg reported that Illumina was in talks to buy their former spinout for up to $8 billion.

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Roche vaults to the front of the NL­RP3 clin­i­cal race, pay­ing $448M up­front to bag In­fla­zome

Roche is going all in on NLRP3.

The pharma giant is putting down $448 million (€380 million) upfront to snatch Novartis-backed Inflazome, which makes it a clinical player in the space overnight.

Dublin and Cambridge, UK-based Inflazome is the second NLRP3-focused biotech Roche has acquired in less than two years, and although no numbers were disclosed in the Jecure buyout, this is almost certainly a much larger deal.

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#ES­MO20: Bris­tol My­ers marks Op­di­vo's sec­ond ad­ju­vant win — eye­ing a stan­dard of care gap

Moving into earlier and earlier treatment lines, Bristol Myers Squibb is reporting that adjuvant treatment with Opdivo has doubled the time that esophageal or gastroesophageal junction cancer patients stay free of disease.

With the CheckMate-577 data at ESMO, CMO Samit Hirawat said, the company believes it can change the treatment paradigm.

While a quarter to 30% of patients typically achieve a complete response following chemoradiation therapy and surgery, the rest do not, said Ronan Kelly of Baylor University Medical Center. The recurrence rate is also high within the first year, Hirawat added.

Donald Trump, AP

Covid-19 roundup: Trump sug­gests Pfiz­er vac­cine could be first ap­proved; VBI Vac­cines inks de­vel­op­ment deal with Cana­da

President Donald Trump commented Monday morning that Pfizer’s Covid-19 vaccine candidate could be the first to win approval by regulators.

During an interview on a Fox News’ morning show, the president said Pfizer was doing “very well” when asked which candidate could be approved, according to a Reuters report. He added that J&J could follow up afterward, saying “they’ll probably be a little later.”

Is­raeli biotech rais­es $57M to go where cur­rent BRAF in­hibitors can't, with back­ing from No­var­tis, SR One

For the blockbuster potential of Novartis’ Tafinlar and Pfizer’s Braftovi, all the BRAF inhibitors on the market so far only target V600 mutations — which accounts for roughly 50% of patients.

Israeli biotech Novellus now has $57 million to develop a drug that they say can help the other 50% who have everything else.

The Series C will fund a Phase II trial for PLX-8394, a “paradox breaker” that could block RAF without activating MAPK signaling. In a Phase I trial, a patient with a BRAF fusion saw their tumor go away after taking the drug, allowing Novellus to hit the ground running.