Feng Zhang's lab de­vel­ops po­ten­tial break­through in RNA edit­ing de­liv­ery us­ing 'ul­tra­com­pact' ver­sions of Cas13

As one of the pi­o­neers be­hind CRISPR, the Broad In­sti­tute’s Feng Zhang has fash­ioned him­self in­to a gene edit­ing Re­nais­sance man in re­cent years with a fin­ger in every pie. For RNA edit­ing, one of his pas­sion projects, Zhang has worked to crack a chron­ic de­liv­ery log­jam — and his team has just made a big break­through there.

A team of re­searchers out of Zhang’s lab has built a pair of “ul­tra­com­pact” RNA edit­ing tools that can fit in­side an ade­no-as­so­ci­at­ed virus (AAV) pack­age, po­ten­tial­ly cre­at­ing a break­through in the de­liv­ery of those gene edit­ing tools in­to hu­man cells, ac­cord­ing to an ar­ti­cle pub­lished in Na­ture Biotech­nol­o­gy on Mon­day.

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