French VC Sev­en­ture fo­cus­es sec­ond fund on fer­tile mi­cro­bio­me field — tar­gets €200M-plus

A few years ago, the spec­tac­u­lar fail­ure of Seres Ther­a­peu­tics’ sem­i­nal ef­fort in­to de­vel­op­ing a “crap­sule” — a syn­thet­ic, fer­ment­ed mi­cro­bio­me ther­a­peu­tic de­rived by a man­u­fac­tur­ing process that does not re­quire hu­man donor ma­te­r­i­al — de­railed an emerg­ing field work­ing to har­ness the in­sights gained from gut mi­cro­bio­ta to de­vel­op drugs. But since then, the suc­cess of fe­cal trans­plant ther­a­pies to treat stub­born­ly re­cur­rent C. diff in­fec­tions has en­tered the bio­phar­ma zeit­geist, at­tract­ed a buck­et of biobucks and even in­spired the takeover of a key play­er, Re­bi­otix. The ther­a­peu­tic ef­fort has resurged along­side a bur­geon­ing in­ter­est in nu­tri­tion — think pro­bi­otics. French VC Sev­en­ture Part­ners has fin­gers in every mi­cro­bio­me pie — drugs, di­ag­nos­tics, dig­i­tal of­fer­ings and nu­tri­tion — and it has launched its sec­ond ded­i­cat­ed mi­cro­bio­me fund with a tar­get of more than €200 mil­lion.

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