Glax­o­SmithK­line’s Hal Bar­ron poach­es Genen­tech’s top can­cer drug deal­mak­er for his new R&D team

Any­one look­ing for fresh hints about GSK’s up­com­ing move on the can­cer front needs to check out the phar­ma gi­ant’s lat­est hire.

New GSK R&D chief Hal Bar­ron has re­cruit­ed Kevin Sin, the long­time on­col­o­gy BD chief at Genen­tech, to the top job on the deal side of the com­pa­ny. His new of­fi­cial ti­tle is head of world­wide busi­ness de­vel­op­ment. And he’ll be mov­ing in­to Bar­ron’s new of­fice be­ing set up in San Fran­cis­co.

Bar­ron and Sin worked to­geth­er at Genen­tech, where Sin had a hand in more than 100 trans­ac­tions, ac­cord­ing to a spokesper­son for GSK.

Hal Bar­ron

GSK has been mar­shal­ing its forces for a move on on­col­o­gy ever since Em­ma Walm­s­ley was pro­mot­ed to the CEO slot. The first clue came when Dana-Far­ber chief Lau­rie Glim­ch­er was brought on to the board af­ter Walm­s­ley poached her from Bris­tol-My­ers. Hal Bar­ron, a leg­end in can­cer re­search cir­cles from his own stint at Genen­tech, then took the top re­search spot. And Bar­ron raised a few eye­brows with GSK’s de­ci­sion to let him stay in the Bay Area, even though GSK’s re­search ops are clus­tered around Philadel­phia and Steve­nage in the UK.

GSK’s can­cer re­search in par­tic­u­lar is in the Philadel­phia area, where Ax­el Hoos has been in charge of shep­herd­ing the ear­ly-stage work that was left at the phar­ma gi­ant af­ter they swapped out their can­cer drug port­fo­lio with No­var­tis in ex­change for some vac­cines.

Luke Miels

Glax­o­SmithK­line has been a no­to­ri­ous lag­gard on the drug de­vel­op­ment side of the busi­ness, fail­ing to achieve the kind of land­mark ap­provals need­ed to grow a port­fo­lio. Walm­s­ley — who al­so wres­tled Luke Miels away from As­traZeneca as the top phar­ma chief — has now set out to change things with a brand new team.

Sin had this to say about the new job hunt­ing down fresh col­lab­o­ra­tions for GSK:

The in­cred­i­ble pace of sci­en­tif­ic and tech­ni­cal in­no­va­tion that is hap­pen­ing around the world is sig­nif­i­cant and presents an abun­dance of op­por­tu­ni­ties to com­bine GSK’s strengths and ca­pa­bil­i­ties with that of oth­ers to pur­sue big ideas in sci­ence and med­i­cine. I look for­ward to work­ing with the team to ex­plore col­lab­o­ra­tions that can ac­cel­er­ate the dis­cov­ery and de­vel­op­ment of new med­i­cines with the po­ten­tial to sig­nif­i­cant­ly im­prove hu­man health.

'Chang­ing the whole game of drug dis­cov­ery': Leg­endary R&D vet Roger Perl­mut­ter leaps back in­to work as a biotech CEO

Roger Perlmutter needs no introduction to anyone remotely involved in biopharma. As the R&D chief first at Amgen and then Merck, he’s built a stellar reputation and a prolific career steering new drugs toward the market for everything from cancer to infectious diseases.

But for years, he’s also held a less known title: science partner at The Column Group, where he’s regularly consulted about the various ideas the VCs had for new startups.

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The DCT-OS: A Tech­nol­o­gy-first Op­er­at­ing Sys­tem - En­abling Clin­i­cal Tri­als

As technology-enabled clinical research becomes the new normal, an integrated decentralized clinical trial operating system can ensure quality, deliver consistency and improve the patient experience.

The increasing availability of COVID-19 vaccines has many of us looking forward to a time when everyday things return to a state of normal. Schools and teachers are returning to classrooms, offices and small businesses are reopening, and there’s a palpable sense of optimism that the often-awkward adjustments we’ve all made personally and professionally in the last year are behind us, never to return. In the world of clinical research, however, some pandemic-necessitated adjustments are proving to be more than emergency stopgap measures to ensure trial continuity — and numerous decentralized clinical trial (DCT) tools and methodologies employed within the last year are likely here to stay as part of biopharma’s new normal.

UP­DAT­ED: Pfiz­er hits the brakes on their piv­otal tri­al for a BC­MA/CD3 bis­pe­cif­ic on safe­ty con­cerns while FDA road­block is hold­ing up Duchenne MD PhI­II

Pfizer’s ambitious plan to take a Phase II study of its BCMA CD3-targeted bispecific antibody elranatamab (PF-06863135) and run it through to an accelerated approval has derailed.

The pharma giant said in a release this morning that they have halted enrollment for their MagnetisMM-3 study after researchers tracked three cases of peripheral neuropathy in the ongoing Phase I. They are now sharing info with the FDA as they explore the red safety flag.

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Cynthia Butitta (L) and Joe Jimenez

Is that an­oth­er IPO in the mak­ing? Ex-No­var­tis CEO Joe Jimenez and a lead Kite play­er take up new posts at an off-the-shelf ri­val to 2 pi­o­neer­ing drugs

Right on the heels of taking on a $160 million crossover round in a likely leap to Nasdaq, Century Therapeutics CEO Lalo Flores is now pushing ahead with the high-profile ex-Novartis chief Joe Jimenez as chairman.

Jimenez’s greatest fame at Novartis was earned for one of its weakest products, as their pioneering personalized CAR-T Kymriah won the honors for the first such drug to make it to the market. Now a host of players, including Century, are barreling in behind the frontrunners with allogeneic rivals that can be created for off-the-shelf use.

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Stéphane Bancel at the Endpoints #JPM20 breakfast panel in San Francisco, January 2020 (Photo: Jeff Rumans, Endpoints News)

Mod­er­na says Covid-19 vac­cine boost­er in­creased im­mune re­sponse against vari­ants of con­cern

About a month after announcing their variant-specific Covid-19 vaccine boosters showed promising results in mice, Moderna says it now has some human data to back it up.

Volunteers given a booster shot about six to eight months after receiving their second dose saw increased antibody levels against SARS-CoV-2 and two variants of concern: B.1.351, which was first identified in South Africa, and P.1, first identified in Brazil, the company said on Wednesday.

FDA ex­tends re­search agree­ment with MIT-li­censed or­gan-on-chip sys­tems

The FDA on Wednesday extended its four-year agreement with CN Bio, a developer of single- and multi-organ-on-chip systems used for drug discovery, for another three years.

CN Bio said the scope of the research performed by the FDA’s Center for Drug Evaluation and Research has expanded to include the exploration of the company’s lung-on-a-chip system to help with the agency’s evaluation of inhaled drugs, in addition to the agency’s work on its liver model.

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In quest to meet user fee goals, FDA’s per­for­mance con­tin­ues down­ward trend

A recent update to the FDA’s running tally of how it’s meeting its user fee-related performance goals during the pandemic shows an agency that is not out of the woods yet.

The latest numbers reveal that for a second straight quarter in 2021, the FDA has met its user fee goal dates for 93% of original new drug applications, which compares with 94% and 98% for the previous two quarters in 2020, respectively.

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Joe Wiley, Amryt CEO

A biotech with a yen for pricey rare dis­ease drugs — and bar­gain base­ment shop­ping — adopts an­oth­er or­phan in lat­est M&A pact

After making it through a long, painful haul to get past a CRL and on to an FDA approval last summer, little Chiasma has found a buyer.

Amryt $AMYT, a company known for its appetite for acquiring expensive drugs for rare diseases at bargain prices, snagged Chiasma and its acromegaly drug Mycapssa (octreotide) capsules in an all-stock deal — with an exchange of 0.396 shares of Amryt for every share of Chiasma.

Ngozi Okonjo-Iweala, Director general of WTO (AP Photo/Keystone/Alessandro Della Bella)

Opin­ion: Waiv­ing Covid-19 vac­cine IP could save lives, but where is the man­u­fac­tur­ing ca­pac­i­ty?

Droves of House Democrats in Washington and members of the European Parliament have now glommed onto a major push by India and South Africa at the WTO to abolish all IP around Covid-19 vaccines.

At first blush, waiving this IP sounds like an easy win: More Covid-19 vaccines made locally for more people means more lives saved. Simple enough, especially as low-income countries have received just a tiny fraction of the world’s vaccine allotment so far.