Hans Bish­op gets a $287M pay­day as Juno ex­ecs see wind­fall for­tunes — with a $922M pay­off for Arch

In every big biotech buy­out the big win­ners are the share­hold­ers and every top ex­ec­u­tive at the com­pa­ny. And Juno Ther­a­peu­tics is no ex­cep­tion.

In their lat­est SEC fil­ing the biotech spelled out the wind­fall for­tunes that await­ed the ex­ec­u­tive crew, in­clud­ing the new­ly re­cruit­ed R&D chief Sunil Agar­w­al.

Top earn­ers gar­nered the most cash, start­ing with CEO Hans Bish­op.

Bish­op’s stock in the com­pa­ny is worth $205 mil­lion, with an ad­di­tion­al set of vest­ed and un­vest­ed op­tions reg­is­ter­ing $68 mil­lion and an­oth­er $8.6 mil­lion in re­strict­ed shares. That’s a $281.6 mil­lion pay­day, plus an­oth­er two years salary — $1.3 mil­lion cash — to get through the tran­si­tion. There’s al­so cov­ered CO­BRA and $3.4 mil­lion for his gold­en para­chute tax­es.

Sunil Agar­w­al

CFO Steve Harr has a stock pile worth $56.5 mil­lion with $29 mil­lion in op­tions and $7.4 mil­lion in re­strict­ed shares. That’s about $93 mil­lion.

Oth­er stand­outs in­clude gen­er­al coun­sel Bernard “Bar­ney” Cas­sidy, with $27 mil­lion in shares, as well as Agar­w­al with about $20 mil­lion worth of op­tions af­ter less than 10 months on the job.

Robert Nelsen

One of the grand prize win­ners, though, is board mem­ber Robert Nelsen, who helped get the whole thing go­ing, raised hun­dreds of mil­lions of dol­lars and point­ed Juno in­to the front ranks of the CAR-T lead­ers, nev­er los­ing faith even in the dark days of their lead drug’s lethal im­plo­sion dur­ing a piv­otal study.

Nelsen’s Arch Ven­ture owns $922,479,618 worth of stock in Juno. And that’s a lot of A rounds to come.

Arch went in­to the Juno deal think­ing big. And they won big.


Im­age: Hans Bish­op Bloomberg via Get­ty Im­ages

UP­DAT­ED: Roche bags 'break­through' an­ti-fi­bro­sis drug in $1.4B biotech buy­out deal

Roche is snapping up a “breakthrough” anti-fibrotic drug in a $1.4 billion buyout.

The pharma giant announced Friday that it is acquiring Promedior, primarily to get its hands on PRM-151, a recombinant form of human pentraxin-2 (PTX-2) protein that has nailed down mid-stage clinical data on idiopathic pulmonary fibrosis and demonstrating its potential for a range of fibrotic conditions.

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Amarin emerges from an ex­pert pan­el re­view with a clear en­dorse­ment for Vas­cepa and high odds of suc­cess when the FDA weighs in for­mal­ly

Several FDA experts who gathered Thursday to consider the landmark approval of Vascepa to reduce cardio events in an at-risk population voiced their unease about various aspects of the efficacy and safety data, or ultimately the population it should be used to treat. But the overwhelming belief that the data pointed to the drug’s benefit and clearly outweighed risks carried the day for Amarin.

The panel voted unanimously (16 to 0) to support the company’s positive data presentation — backing an OK for expanding the label to include reducing cardio risk. The vote points Amarin $AMRN down a short path to a formal decision by the FDA, with the odds heavily in its favor. Chances are the rest of the questions about the future of this drug will be hashed out in the label’s small print.

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Federal Trade Commission commissioner Rohit Chopra testifies on Capitol Hill (AP Photo/Susan Walsh)

FTC clears Bris­tol-My­ers’ $74B deal to buy Cel­gene — but Dems sig­nal a po­ten­tial hard shift against Big Phar­ma M&A

Bristol-Myers Squibb’s record $74 billion takeover of Celgene is a done deal. And it will all be over — except for the lingering complaints from die-hard Celgene investors — on Wednesday.

Like much else that’s going on in Washington these days, the vote among the 5 FTC commissioners split along party lines, with the 3 Republicans voting to clear the way and the 2 Democrats steamed over what they see as a major M&A move that will lessen competition and innovation. And that split has big implications for the M&A side of the business if the Dems take the White House in 2020.

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No­var­tis spin­out’s first an­ti-ag­ing PhI­II is a flop, so now they’ll turn to Parkin­son’s chal­lenge as shares wilt

Novartis spinout resTORbio is grappling with the collapse of its lead clinical program this morning — an anti-aging R&D failure that will badly damage their rep in the field.

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BeiGene CEO John Oyler at an Endpoints event in Shanghai, October 2018 (Credit: Endpoints News/PharmCube)

UP­DAT­ED: In a first, FDA green-lights use of a Chi­nese built can­cer ther­a­py — and more are com­ing

Weeks after Amgen took a $2.7 billion stake in BeiGene, the Beijing-based biotech has secured its first-ever FDA approval for zanubrutinib, a BTK inhibitor, months ahead of schedule.

BeiGene’s drug, branded as Brukinsa, has secured accelerated approval for adult patients with mantle cell lymphoma (MCL) — a typically aggressive, rare, form of blood cancer — who have received at least one prior therapy.

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What does $62B buy you these days? A lot, says Take­da ex­ecs as the phar­ma play­er promis­es a block­buster R&D fu­ture

First comes the $62 billion buyout. Then comes the asset auction and reorganization to pay down debt. Now comes the detailed pledge of a bigger, brighter future in drug development.

That’s where Takeda finds itself on R&D day today, about 11 months after closing on their Shire acquisition. R&D chief Andy Plump is joining CEO Christophe Weber and other top members of the team to outline a new set of priorities in the greatly expanded pipeline at Takeda, which has jumped into the top ranks of the world’s pharma giants in the wake of the Shire deal.

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GSK's asth­ma bi­o­log­ic Nu­cala scores in rare blood dis­or­der study

GlaxoSmithKline’s asthma drug Nucala, which received a resounding FDA rejection for use in chronic obstructive pulmonary disease (COPD) last year, has shown promise in a rare blood disorder.

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Mer­ck buys a fledg­ling neu­rode­gen­er­a­tive biotech spawned by an old GSK dis­cov­ery al­liance. What’s up with that?

Avalon Ventures chief Jay Lichter has a well-known yen for drug development programs picked up in academia. And what he found in Haoxing Xu’s lab at the University of Michigan pricked his interest enough to launch one of his umbrella biotechs in San Diego.

Xu’s work laid the foundation for Avalon to launch Calporta, which has been working on finding small molecule agonists of TRPML1 (transient receptor potential cation channel, mucolipin subfamily, member 1) for lysosomal storage disorders. And that pathway, they believe, points to new approaches on major market neurodegenerative diseases like Parkinson’s, ALS and Alzheimer’s.

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No­var­tis scores its lat­est FDA OK — this time for a new sick­le cell dis­ease drug picked up in a $665M deal

Novartis’ decision to buy Oklahoma-based biotech Selexys 3 years ago for up to $665 million has paid off with an FDA approval today.

Blessed with the FDA’s breakthrough drug designation for a speedy review, the pharma giant has pinned down an approval for crizanlizumab, a new therapy designed to reduce the frequency of painful incidents of vaso-occlusive crises among sickle cell disease patients 16 or older.

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