Har­vard prof David Sin­clair backs an­ti-ag­ing up­start Life Bio, which just raised $50M for re­search

You can add Life Bio­sciences to the list of biotech star­tups look­ing to make a name for them­selves in the bur­geon­ing field of an­ti-ag­ing drug re­search.

David Sin­clair

The Boston-based biotech — which has close ties to David Sin­clair, a Har­vard ge­neti­cist who’s been in­volved in a va­ri­ety of star­tups — says to­day that it’s lined up $50 mil­lion in B round cash. There’s no word on who ex­act­ly is in­vest­ing in the com­pa­ny, but there’s no short­age of am­bi­tion.

Tris­tan Ed­wards

“We have un­der­tak­en a big land-grab of longevi­ty-re­lat­ed in­tel­lec­tu­al prop­er­ty and we have pulled to­geth­er a lot of the world’s longevi­ty sci­en­tists,” Life CEO Tris­tan Ed­wards told the Fi­nan­cial Times in a pre­view of the an­nounce­ment. Ed­wards co-found­ed the com­pa­ny along­side Sin­clair.

The FT notes that the mon­ey is com­ing from wealthy in­vestors at­tract­ed to the longevi­ty field, but al­so of­fers no specifics. The re­port adds that the com­pa­ny val­u­a­tion is set at an es­ti­mat­ed $500 mil­lion.

Life’s claim to fame is that it’s pur­su­ing what the team de­scribes as “all 8” path­ways in­volved in ag­ing, which in­cludes some fa­mil­iar tar­gets rang­ing from cell senes­cence to stem cell ex­haus­tion and mi­to­chon­dria dys­func­tion re­lat­ed to the body’s bat­tery packs. And they’ve es­tab­lished 6 sub­sidiary units to go af­ter these tar­gets in a col­lab­o­ra­tive fash­ion, with Senolyt­ic go­ing af­ter the old cells that ac­cu­mu­late in our bod­ies as we grow old­er.

Ed­wards is a trans­plant from Aus­tralia, which may help ex­plain why Life just days ago in­vest­ed $7.5 mil­lion in Prana Biotech­nol­o­gy $PRAN, a small Mel­bourne-based out­fit that’s been en­gaged for years in high-risk neu­rode­gen­er­a­tion work.

An­ti-ag­ing re­search has looped in a va­ri­ety of play­ers, from Google’s Cal­i­co to Uni­ty and Ju­ve­nes­cence. Oth­ers in biotech are tar­get­ing ag­ing re­lat­ed dis­eases, like mus­cle weak­ness, but go­ing af­ter spe­cif­ic ail­ments along the path to longevi­ty.

Image courtesy of The Janssen Pharmaceutical Companies of Johnson & Johnson.

Pro­tect­ing the glob­al phar­ma­ceu­ti­cal in­no­va­tion ecosys­tem – what’s at stake?

We are living in a new era of healthcare that is rapidly advancing progress impacting patient outcomes and experiences. We’ve seen a remarkable pace of transformational innovation, applied research, and advanced clinical development over the last decade.

Despite this tremendous progress, there is much more work to be done, and patients are counting on us – now more than ever – to continue that momentum. At the heart of our industry is a focus on developing and delivering medicines for some of the world’s most challenging diseases, including those that have few or no effective treatments today.

Roger Perlmutter, Eikon Therapeutics CEO

Roger Perl­mut­ter builds Eikon's pipeline with deal-mak­ing flur­ry, rais­ing $106M more

Eikon Therapeutics announced three business development deals on Thursday, effectively dropping in a pipeline of cancer drugs alongside more than $100 million in fresh funding.

The Hayward, CA-based company has become one of biotech’s richest startups since its 2019 founding, having raised nearly $775 million. It’s developing a massive, automated research approach built around Nobel Prize-winning microscope science to peer inside cells and watch proteins in action. After its Series B last year, PitchBook reported a $3.02 billion valuation. And while CEO Roger Perlmutter declined to comment on that figure, he said its first tranche of nearly $106 million in Series C funding is a “meaningful step-up to our Series B valuation.”

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The Modulo Bio team with CEO Michael Horowitz (fourth from right in semicircle)

Ex­clu­sive: With $8M, neu­ro start­up Mod­u­lo Bio emerges to test small mol­e­cules for ALS, de­men­tia in CEO’s per­son­al mis­sion

Embarking on a personal mission after his best friend’s mother was diagnosed with a mutation-driven case of frontotemporal dementia, Michael Horowitz has pulled together $8 million in venture funding at Modulo Bio to create small molecules for neurodegenerative diseases.

The San Diego and Bay Area biotech will select its lead development candidate and some backup options within six months and then raise a Series A to investigate therapeutics for C9orf72 mutation-driven cases of ALS and frontotemporal dementia, Horowitz told Endpoints News.

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RA Cap­i­tal-backed non-vi­ral gene ther­a­py start­up Sum­ma­tion Bio to shut down

As a string of new gene therapy startups aims to create treatments without the go-to shuttling method of an AAV virus, and as multiple gene editing biotechs look to do the same, one such startup is coming to a close.

Summation Bio, backed by at least $24 million in Series A funds, is “terminating operations” next month, per an employee’s LinkedIn profile update. (According to their LinkedIn profile, an employee said the company raised $60 million in the round.) Another employee took to the networking site last week to say the circumstances were “insurmountable,” noting that “despite all-out effort and error-free execution, the science, this time, was elusive.”

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Eu­ro­pean Par­lia­ment calls mem­ber states to ac­tion on an­timi­cro­bial re­sis­tance

Members of the European Parliament have called on EU countries to develop national action plans against antimicrobial resistance (AMR), calling it a top-three priority health threat.

Parliament on Thursday announced recommendations for the fight against AMR, including national action plans that must be updated at least every two years, an EU-level database tracking AMR and antimicrobial use and increased partnership between the pharma industry, patient groups and academia.

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San­doz plans to stay lo­cal af­ter No­var­tis sep­a­ra­tion, se­lect­ing new HQ in Basel

Sandoz, a generics maker that Novartis plans to spin off later this year, has picked its new headquarters — and it’s only 2.4 miles away from its current digs on the Novartis campus.

The Novartis unit said Thursday that it plans to move to an office building in Basel called Elsässertor sometime in mid-2024.

Sandoz CEO Richard Saynor said in a news release that the location in the heart of Basel “will allow us to create a working environment that meets our business needs,” citing the talent pool in the Swiss city. Sandoz added that the workspace is designed to allow for “closer collaboration and teamwork.”

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Bausch + Lomb to pro­mote three SVPs to ex­ec­u­tive team

Bausch + Lomb is making more executive change-ups, including the promotion of three of its senior VPs that will report directly to CEO Brent Saunders.

Earlier this year, Saunders returned to lead Bausch + Lomb and its roughly 12,000 employees after originally running the company from 2010 to 2013.

Bausch + Lomb said Thursday that Luc Bonnefoy, John Ferris and Yang Yang — the leaders of its surgical, consumer and vision care businesses, respectively — will join the executive management team and report directly to Saunders. It also said that Joseph Gordon, head of global consumer, surgical and vision care, is now a strategic advisor to Saunders.

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Roche plans to di­vest from lega­cy Genen­tech man­u­fac­tur­ing fa­cil­i­ty in Cal­i­for­nia

Roche is planning to make some changes to its subsidiary’s manufacturing network in California.

The Swiss pharma announced Wednesday that it plans to divest from Genentech’s manufacturing facility in Vacaville, CA, around 58 miles northeast of San Francisco. According to a statement from Roche, the move is part of a “broader strategy” to bring its manufacturing capabilities in line with its future pipeline. Roche is starting the process of finding a buyer for the site but has not named any candidates yet.

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Far­al­lon says it's won all de­sired board seats from Ex­elix­is af­ter share­hold­er vote

Less than two months after Farallon Capital Management launched a proxy fight to gain control of three seats on cancer biotech Exelixis’ board, it got what it wanted at the company’s annual shareholder meeting.

The hedge fund said Wednesday that preliminary results at Exelixis’ annual shareholder meeting elected all three of Farallon’s candidates to the board: Tom Heyman, Dave Johnson and Bob Oliver.

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