How much has pre­ci­sion med­i­cine helped? A new NCI study of­fers clues but pro­vokes skep­tics

Does pre­ci­sion med­i­cine work?

The ap­proach, based on find­ing a drug to tar­get a pa­tient’s spe­cif­ic genes, has un­doubt­ed­ly saved in­di­vid­ual lives, spurring Lazarus-like re­ver­sals in health in once-ter­mi­nal­ly ill pa­tients. But crit­ics have point­ed out that its pur­suit has meant drug com­pa­nies spend­ing hun­dreds of mil­lions of dol­lars to tar­get mu­ta­tions that af­fect nar­row slices of the pop­u­la­tions, and that many of the gains re­searchers thought it would bring have erod­ed as can­cers evolve re­sis­tance.

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