In staggering setback, toxic reaction kills Cellectis’ first CAR-T patient, forcing trial halt
The FDA has forced Cellectis $CLLS to slam the brakes on two clinical trials of its off-the-shelf version of a CAR-T therapy after their first patient was killed by a lethally toxic reaction to treatment.
According to the biotech, which is based in Paris with R&D operations in New York, a 78-year-old patient suffering from blastic plasmacytoid dendritic cell neoplasm (BPDCN) died eight days after receiving the biotech’s first dose of the cell therapy. He experienced a lethal reaction as cytokine release syndrome hit, along with a grade 4 case of capillary leak syndrome. A separate study which also treated one patient is underway for acute myeloid leukemia.
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