J&J chief Alex Gorsky suf­fers a big drop in com­pen­sa­tion, but still comes out way ahead of most ma­jor league CEOs

J&J CEO Alex Gorsky took home a se­ri­ous­ly di­min­ished com­pen­sa­tion pack­age for 2018, but there’s no need to add him to your prayer list as he still brought home one of the biggest CEO pay­days record­ed so far this year in the gi­ant phar­ma cat­e­go­ry.

Add it all up and the bio­phar­ma con­glom­er­ate chief earned a pack­age worth a bit over $20 mil­lion. That’s a steep drop from $29.8 mil­lion record­ed for 2017, with a de­cline of $2 mil­lion for his stock op­tions and a wipe­out on pen­sion val­ue. His salary ticked up a tee­ny bit to $1.64 mil­lion, but it’s the eq­ui­ty por­tions that of­fer the up­side when you play in the big leagues.

Paul Stof­fels

That change on pen­sions was re­flect­ed for the en­tire top team at J&J, in­clud­ing CSO Paul Stof­fels, who net­ted $10.6 mil­lion, down from $13.6 mil­lion. Joaquin Du­a­to, the vice chair­man of the ex­ec­u­tive com­mit­tee, grabbed a com­pen­sa­tion pack­age worth $9.3 mil­lion, a $10 mil­lion plunge.

Run­ning a glob­al Big Phar­ma com­pa­ny like J&J has its ups and downs. Like the rest of the top 15 play­ers in the busi­ness, J&J has to con­tend with some fierce blow­back on US prices. Its big drug Xarel­to saw a sig­nif­i­cant dip in sales in Q4 due to dis­count­ing. And its old­er drugs are no longer tapped for an­nu­al price hikes, flat­ten­ing rev­enue pro­jec­tions for 2019.

Joaquin Du­a­to

J&J, though, has some suc­cess­es it can boast about, in­clud­ing a re­for­mu­lat­ed nasal spray ver­sion of ke­t­a­mine for se­vere de­pres­sion, re­cent­ly ap­proved by the FDA. 

Gorsky’s de­cline in for­tunes still leaves him a close sec­ond on the list of top earn­ers in his ech­e­lon of ex­ecs, right be­hind Ab­b­Vie chief Richard Gon­za­lez, who’s been rid­ing the Hu­mi­ra gravy train while de­vel­op­ing new drugs. And he’s way ahead of last-place fin­ish­er Em­ma Walm­s­ley, with a $7.67 mil­lion com­pen­sa­tion pack­age at GSK.


Im­age: Alex Gorsky dur­ing a meet­ing with Pres­i­dent Don­ald Trump, 2017. AP IM­AGES

On a glob­al romp, Boehringer BD team picks up its third R&D al­liance for Ju­ly — this time fo­cused on IPF with $50M up­front

Boehringer Ingelheim’s BD team is on a global deal spree. The German pharma company just wrapped its third deal in 3 weeks, going back to Korea for its latest pipeline pact — this time focused on idiopathic pulmonary fibrosis.

They’re handing over $50 million to get their hands on BBT-877, an ATX inhibitor from Korea’s Bridge Biotherapeutics that was on display at a science conference in Dallas recently. There’s not a whole lot of data to evaluate the prospects here. Researchers noted a dose-dependent increase of plasma concentrations of the drug in an interim review of their Phase I, primarily spotlighting safety and tolerability. And Bridge has touted preclinical data they say makes this a best-in-class contender.

Servi­er scoots out of an­oth­er col­lab­o­ra­tion with Macro­Gen­ics, writ­ing off their $40M

Servier is walking out on a partnership with MacroGenics $MGNX — for the second time.

After the market closed on Wednesday MacroGenics put out word that Servier is severing a deal — inked close to 7 years ago — to collaborate on the development of flotetuzumab and other Dual-Affinity Re-Targeting (DART) drugs in its pipeline.

MacroGenics CEO Scott Koenig shrugged off the departure of Servier, which paid $20 million to kick off the alliance and $20 million to option flotetuzumab — putting a heavily back-ended $1 billion-plus in additional biobuck money on the table for the anti-CD123/CD3 bispecific and its companion therapies.

Den­mark's Gen­mab hits the jack­pot with $500M+ US IPO as small­er biotechs rake in a com­bined $147M

Danish drugmaker Genmab A/S is off to the races with perhaps one of the biggest biotech public listings in decades, having reaped over $500 million on the Nasdaq, as it positions itself as a bonafide player in antibody-based cancer therapies.

The company, which has long served as J&J’s $JNJ key partner on the blockbuster multiple myeloma therapy Darzalex, has asserted it has been looking to launch its own proprietary product — one it owns at least half of — by 2025.

FDA over­rides ad­comm opin­ions a fifth of the time, study finds — but why?

For drugmakers, FDA advisory panels are often an apprehended barometer of regulators’ final decisions. While the experts’ endorsement or criticism often translate directly to final outcomes, the FDA sometimes stun observers by diverging from recommendations.

A new paper out of Milbank Quarterly put a number on that trend by analyzing 376 voting meetings and subsequent actions from 2008 through 2015, confirming the general impression that regulators tend to agree with the adcomms most of the time — with discordances in only 22% of the cases.

Norbert Bischofberger. Kronos

Backed by some of the biggest names in biotech, Nor­bert Bischof­berg­er gets his megaround for plat­form tech out of MIT

A little over a year ago when I reported on Norbert Bischofberger’s jump from the CSO job at giant Gilead to a tiny upstart called Kronos, I noted that with his connections in biotech finance, that $18 million launch round he was starting off with could just as easily have been $100 million or more.

With his first anniversary now behind him, Bischofberger has that mega-round in the bank.

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Part club, part guide, part land­lord: Arie Bellde­grun is blue­print­ing a string of be­spoke biotech com­plex­es in glob­al boom­towns — start­ing with Boston

The biotech industry is getting a landlord, unlike anything it’s ever known before.

Inspired by his recent experiences scrounging for space in Boston and the Bay Area, master biotech builder, investor, and global dealmaker Arie Belldegrun has organized a new venture to build a new, 250,000 square foot biopharma building in Boston’s Seaport district — home to Vertex and a number of up-and-coming biotech players.

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H1 analy­sis: The high-stakes ta­ble in the biotech deals casi­no is pay­ing out some record-set­ting win­nings

For years the big trend among dealmakers at the major players has been centered on ratcheting down upfront payments in favor of bigger milestones. Better known as biobucks for some. But with the top 15 companies competing for the kind of “transformative” pacts that can whip up some excitement on Wall Street, with some big biotechs like Regeneron now weighing in as well, cash is king at the high stakes table.

We asked Chris Dokomajilar, the head of DealForma, to crunch the numbers for us, looking over the top 20 deals for the past decade and breaking it all down into the top alliances already created in 2019. Gilead has clearly tipped the scales in terms of the coin of the bio-realm, with its record-setting $5 billion upfront to tie up to Galapagos’ entire pipeline.

Dokomajilar notes:

We’re going to need a ‘three comma club’ for the deals with over $1 billion in total upfront cash and equity. The $100 million-plus club is getting crowded at 164 deals in the last decade with new deals being added towards the top of the chart. 2019 already has 14 deals with at least $100 million in upfront cash and equity for a total year-to-date of over $9 billion. That beats last year’s $8 billion and sets a record.

Add upfronts and equity payments and you get $11.5 billion for the year, just shy of last year’s record-setting $11.8 billion.

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Novotech CRO Ex­pands Chi­na Team as Biotech De­mand for Clin­i­cal Tri­als In­creas­es up to 79%

An increase in demand of up to 79% for clinical trials in China has prompted Novotech the Asia-Pacific CRO to rapidly expand the China team, appointing expert local clinical executives to their Shanghai and Hong Kong offices. The company is planning to expand their team by 30% over the next quarter.

Novotech China has seen considerable demand recently which is borne out by research from GlobalData:
A global migration of clinical research is occurring from high-income countries to low and middle-income countries with emerging economies. Over the period 2017 to 2018, for example, the number of clinical trial sites opened by biotech companies in Asia-Pacific increased by 35% compared to 8% in the rest of the world, with growth as high as 79% in China.
Novotech CEO Dr John Moller said China offers the largest population in the world, rapid economic growth, and an increasing willingness by government to invest in research and development.
Novotech’s 23 years of experience working in the region means we are the ideal CRO partner for USA biotechs wanting to tap the research expertise and opportunities that China offers.
There are over 22,000 active investigators in Greater China, with about 5,000 investigators with experience on at least 3 studies (source GlobalData).

UP­DAT­ED: With loom­ing ‘apoc­a­lypse of drug re­sis­tance,’ Mer­ck’s com­bi­na­tion an­tibi­ot­ic scores FDA ap­proval on two fronts

Merck — one of the last large biopharmaceuticals companies in the beleaguered field of antibiotic drug development — on Wednesday said the FDA had sanctioned the approval of its combination antibacterial for the treatment of complicated urinary tract and intra-abdominal infections.

To curb the rise of drug-resistant bacteria and maintain the efficacy of the therapy, Recarbrio (and other antibacterials) — the drug must be used to treat or prevent infections that are proven or strongly suspected to be caused by susceptible gram-negative bacteria, Merck $MRK said.

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