Drug Development

J&J dumps a failed PhIII antibiotic program picked up in Actelion buyout

J&J is washing its hands of the Phase III Clostridium difficile-associated diarrhea program for the antibiotic cadazolid.

Jean-Paul Clozel

The pharma giant obtained rights to the antibiotic in their $30 billion buyout of Actelion. But as the deal was being completed, cadazolid floundered — hitting the goal posts in one study but missing in another — after recruiting 1,263 patients to compare 250 mg of cadazolid twice daily against 4 daily doses of 125 mg vancomycin.

Typically the FDA requires a success in two pivotal studies to warrant an approval — a standard that has bedeviled a variety of small players like Tetraphase. Last June the execs at Actelion, who were taking some assets and spinning out into a new company called Indorsia, said they’d do a final analysis and determine what to do next.

J&J wrote it off in their quarterly release, saying only that they would discontinue the Phase III program.

J&J won the deal to buy Actelion last year after Sanofi managed to tick off Actelion CEO Jean-Paul Clozel. The cadazolid pact was put in place alongside a partnership on ponesimod, the more closely-watched drug.


The best place to read Endpoints News? In your inbox.

Comprehensive daily news report for those who discover, develop, and market drugs. Join 31,500+ biopharma pros who read Endpoints News by email every day.

Free Subscription

RAPS Convergence 2018

Chief Medical Officer
Skyhawk Therapeutics Waltham, MA
Chief of Staff, North America
Ipsen Biopharmaceuticals Cambridge, MA
Senior Director, NA Digital Customer Interaction
Ipsen Biopharmaceuticals Cambridge, MA
Manufacturing Associate – Upstream
Molecular Templates Austin, TX
Scientist, Process Development
Molecular Templates Austin, TX
GMP Supervisor - Downstream
Molecular Templates Austin, TX
Quality Control (QC) Associate
Molecular Templates Austin, TX

Visit Endpoints Careers ->