J&J is jet­ti­son­ing two of its promised block­buster drugs, and it could­n't come at a worse time

Just 5 months af­ter try­ing to con­vince in­vestors that they were on to a large pipeline of block­busters head­ing to the mar­ket, J&J has al­ready de­cid­ed that two of them are es­sen­tial­ly worth­less, or just too dan­ger­ous to use.

The writ­ing was al­ready on the wall months ago for sirukum­ab, once a top prospect for rheuma­toid arthri­tis un­til its part­ners at Glax­o­SmithK­line sud­den­ly walked out. Ear­li­er this year, though, a pan­el of out­side ex­perts vot­ed down the mar­ket­ing ap­pli­ca­tion, fret­ting over an un­ex­plained im­bal­ance in deaths in the study. The in­evitable for­mal re­jec­tion fol­lowed.

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