Joe Jimenez (L) and Mark Fishman (Aditum Bio)

Joe Jimenez and Mark Fish­man sign up their 5th drug can­di­date — and they have an­oth­er big tar­get in their crosshairs

Ex-No­var­tis chief Joe Jimenez and his long­time col­league Mark Fish­man have now ramped up their 5th biotech sub at the up­start Adi­tum. And once again, they’re tack­ling a big, tough mar­ket.

The new out­fit is called An­co­ra Bio, and its drug is a se­lec­tive va­so­pressin 1b re­cep­tor — V1b — an­tag­o­nist from Taisho Phar­ma­ceu­ti­cal that will roll ahead un­der a new code name: ANC-501.

Ev­i­dent­ly this is the same de­pres­sion drug that Taisho test­ed in a re­cent Phase II clin­i­cal study. Some num­bers trend­ed in its fa­vor com­pared to a place­bo but fell short of sta­tis­ti­cal sig­nif­i­cance — just one in a long se­ries of fail­ures for ma­jor de­pres­sion.

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