Michael Ehlers (Replicate)

'Like a kid in a can­dy shop': Michael Ehlers gets be­hind RNA 'copy ma­chine' tech

Nathaniel Wang and An­drew Geall spent years work­ing on self-repli­cat­ing RNAs at Syn­thet­ic Ge­nomics and No­var­tis Vac­cines, re­spec­tive­ly, be­fore they re­al­ized they were com­ing at it the wrong way.

“For years and years, we thought that the tech­nol­o­gy was es­sen­tial­ly plug and play,” Wang said. “It turns out … the vec­tor it­self, the pro­tein that you’re putting in­to that vec­tor, and the fat droplet you use to for­mu­late it be­fore you in­ject it in­to a per­son are all in­de­pen­dent vari­ables.”

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