Mayo team spot­lights the role of senes­cent cells in neu­rode­gen­er­a­tion, start­ing down a path­way that may lead to Alzheimer’s

As an­ti-ag­ing re­search grows around the world, there’s been a big fo­cus on clear­ing away the “senes­cent” cells that clut­ter bod­ies as peo­ple grow old­er. These ag­ing cells lose the abil­i­ty to di­vide and mouse stud­ies have of­fered a pre­clin­i­cal the­o­ry that sweep­ing them away with new drugs can of­fer peo­ple longer, health­i­er lives.

Now a re­search team at the Mayo Clin­ic is of­fer­ing more an­i­mal da­ta to back that up, and they’re shin­ing a light on a new path­way in neu­rode­gen­er­a­tion and specif­i­cal­ly Parkin­son’s and Alzheimer’s — per­haps the sin­gle most frus­trat­ing field in drug de­vel­op­ment.

Ac­cord­ing to the Mayo team, they were able to de­ter­mine that mi­croglia and as­tro­cyte cells were most like­ly to turn in­to rogue zom­bies. By clear­ing these senes­cent cells from the brains of mice, they tar­get­ed a key path­way im­pli­cat­ed in Alzheimer’s, tamped down on in­flam­ma­tion and had an im­pact on mem­o­ry.

“We used a mouse mod­el that pro­duces sticky, cob­web like tan­gles of tau pro­tein in neu­rons and has ge­net­ic mod­i­fi­ca­tions to al­low for senes­cent cell elim­i­na­tion,” ex­plains first au­thor Tyler Buss­ian, a Mayo Clin­ic Grad­u­ate School of Bio­med­ical Sci­ences stu­dent. “When senes­cent cells were re­moved, we found that the dis­eased an­i­mals re­tained the abil­i­ty to form mem­o­ries, elim­i­nat­ed signs of in­flam­ma­tion, did not de­vel­op neu­rofib­ril­lary tan­gles, and had main­tained nor­mal brain mass.”

The work was pub­lished in Na­ture.

It’s a big leap — and an in­cred­i­bly com­plex chal­lenge — to go from a dis­ease mod­el in pre­clin­i­cal stud­ies to test­ing this con­cept in hu­mans. But bil­lions have been spent on Alzheimer’s with noth­ing but fail­ure to show for it. The theme now is try­ing new things, with a bet­ter un­der­stand­ing that bend­ing the curve of neu­rode­gen­er­a­tion in pa­tients who ex­hib­it symp­toms of their dis­ease will be ex­tra­or­di­nar­i­ly dif­fi­cult.

The most ad­vanced biotech in the senes­cence field is an up­start called Uni­ty, which was able to trans­late their pre­clin­i­cal work in­to a Phase I which starts with os­teoarthri­tis. But in­ves­ti­ga­tors in the field — in­clud­ing the team at Uni­ty — be­lieve they’re on a trail that leads to a host of ail­ments.

Alzheimer’s just may be one of them.

Im­age: Dar­ren Bak­er, se­nior au­thor, and Tyler Buss­ian.MAYO CLIN­IC

Com­mu­ni­cat­ing the val­ue of pre­ci­sion med­i­cine

By Natasha Cowan, Content Marketing Manager at Blue Latitude Health.
Many stakeholders are confused by novel precision medicines, including patients and healthcare professionals. So, how can industry help them to navigate this complexity?

Precision medicine represents a new paradigm in healthcare. It embodies the shift from treating many patients with the same therapy, to having the tools to identify the best treatment for every patient.

Amir Nashat, World Medical Innovation Forum via Youtube

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Mer­ck buys a fledg­ling neu­rode­gen­er­a­tive biotech spawned by an old GSK dis­cov­ery al­liance. What’s up with that?

Avalon Ventures chief Jay Lichter has a well-known yen for drug development programs picked up in academia. And what he found in Haoxing Xu’s lab at the University of Michigan pricked his interest enough to launch one of his umbrella biotechs in San Diego.
Xu’s work laid the foundation for Avalon to launch Calporta, which has been working on finding small molecule agonists of TRPML1 (transient receptor potential cation channel, mucolipin subfamily, member 1) for lysosomal storage disorders. And that pathway, they believe, points to new approaches on major market neurodegenerative diseases like Parkinson’s, ALS and Alzheimer’s.

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GSK's asth­ma bi­o­log­ic Nu­cala scores in rare blood dis­or­der study

GlaxoSmithKline’s asthma drug Nucala, which received a resounding FDA rejection for use in chronic obstructive pulmonary disease (COPD) last year, has shown promise in a rare blood disorder.

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Spe­cial re­port: Twen­ty ex­tra­or­di­nary women in bio­phar­ma R&D who worked their way to the top

What differentiates a woman leader in biopharma R&D from a man?

Not much, except there are fewer of them in senior posts. Data suggest women are not more risk-averse, family-oriented or less confident than their male counterparts — indeed the differences between the two sexes are negligible. But a glance at the top R&D positions in Big Pharma leaves little doubt that upward migration in the executive ranks of biopharma R&D is tough.

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FDA Vas­cepa re­view spot­lights new safe­ty sig­nals, pos­si­ble min­er­al oil spoil­er as Amarin hunts a block­buster ap­proval

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The stakes don’t get much higher, with analysts saying a win this week for Amarin could lead to billions in new sales — provided the agency stamps it with an OK. And investors liked what they say in the FDA review this morning, bumping the stock $AMRN 17%.

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FDA puts Sol­id Bio’s lead gene ther­a­py pro­gram on hold — again — af­ter an­oth­er pa­tient is hurt by SGT-001

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Close to 18 months after the gene therapy biotech was able to quickly shed an FDA hold on their lead Duchenne muscular dystrophy program for SGT-001, regulators have stepped back in to force another halt after another patient was hit hard by a set of serious adverse events remarkably similar to the first set.

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FDA slaps a hold on an AML tri­al as Mark­er scraps a fail­ing ovar­i­an can­cer pro­gram, sink­ing shares

The FDA has placed a hold on a Phase II AML trial from the small immuno-oncology biotech Marker Therapeutics. Marker disclosed the issue two weeks after responding to FDA concerns, adding it to the Q3 release Tuesday. The company also announced it was scrapping a Phase II ovarian cancer program it determined was unlikely to succeed.

The agency’s concern centers around two reagents used in manufacturing for their trial for acute myeloid leukemia patients who have received a stem cell transplant. The reagents are from third parties and not present in the final product, Marker said.