Med­i­cines Co ex­ecs grab a $33M A round to spin out an in­fec­tious dis­ease out­fit with a pipeline

Turns out, Melin­ta didn’t bag all of The Med­i­cines Com­pa­ny’s in­fec­tious dis­ease work when they ex­e­cut­ed a buy­out deal last fall. There were some pre­clin­i­cal as­sets in the pipeline as well, and now some of the ex­ecs in­volved have gained the back­ing of in­vestors to use it to cre­ate a pipeline for a start­up ven­ture.

Qpex, which an­nounced the clos­ing of a $33 mil­lion Se­ries A fi­nanc­ing round, now has ac­cess to $MD­CO‘s be­ta-lac­ta­mase in­hibitor tech­nol­o­gy. Be­ta-lac­ta­mases are a fam­i­ly of en­zymes that hy­drolyze and there­by in­ac­ti­vate be­ta-lac­tam an­tibi­otics – a group of an­timi­cro­bials com­pris­ing four ma­jor groups: peni­cillins, cephalosporins, monobac­tams, and car­bapen­ems that are ubiq­ui­tous and ac­count for near­ly half of all pre­scribed an­tibi­otics.

New En­ter­prise As­so­ci­ates led the fi­nanc­ing syn­di­cate and was ac­com­pa­nied by Adams Street Part­ners, LYZZ Cap­i­tal, Hat­teras Ven­ture Part­ners and Stan­ford Uni­ver­si­ty Drap­er Fund.

The un­bri­dled — and oft’ un­nec­es­sary — use of ex­ist­ing an­tibi­otics by health­care prac­ti­tion­ers, and per­va­sive an­tibi­ot­ic use in food live­stock has cul­mi­nat­ed in the evo­lu­tion of an­tibi­ot­ic-re­sis­tant bac­te­ria. The World Health Or­ga­ni­za­tion now con­sid­ers an­tibi­ot­ic re­sis­tance as one of the biggest threats to glob­al health, food se­cu­ri­ty, and de­vel­op­ment, and in the Unit­ed States, the CDC es­ti­mates at least 2 mil­lion peo­ple con­tract an an­tibi­ot­ic-re­sis­tant in­fec­tion each year, and at least 23,000 die as a re­sult. Mean­while, in re­cent years many large drug­mak­ers such as No­var­tis $NVS, As­traZeneca $AZN, Al­ler­gan $AGN and Sanofi $SNY have aban­doned their an­tibi­ot­ic re­search pro­grams in favour of lu­cra­tive cat­e­gories of un­met need such as can­cer and rare dis­eases, that re­quire sim­i­lar R&D in­vest­ments, but com­mand high­er prices and are typ­i­cal­ly used for longer.

Qpex, through its whol­ly-owned in­fec­tious dis­ease sub­sidiary, al­ready has in place a strate­gic part­ner­ship with BAR­DA that pro­vides the po­ten­tial for up to $132 mil­lion to sup­port de­vel­op­ing a port­fo­lio of new an­tibi­otics to fight drug-re­sis­tant, gram-neg­a­tive in­fec­tions.

At the Med­i­cines Co, the team of ex­ec­u­tives spear­head­ed the ap­proval of a com­bi­na­tion drug, Vabomere, that is made up of the an­tibi­ot­ic meropen­em and be­ta lac­ta­mase in­hibitor vabor­bac­tam, to treat com­pli­cat­ed uri­nary tract in­fec­tions, or the old­er Aug­mentin which was ap­proved in 1990’s and is com­mon­ly used to tack­le in­ner ear in­fec­tions. Qpex is bet­ting on these pre­clin­i­cal as­sets to de­vel­op sim­i­lar com­bi­na­tion treat­ments to fight su­per­bugs.

The slow pace of an­tibi­ot­ic ap­provals — on­ly 12 since the year 2000 — makes the space ripe for in­vest­ment. Of the big­ger play­ers, on­ly Mer­ck $MRK, Roche $RHH­BY, Glax­o­SmithK­line $GSK and Pfiz­er $PFE, have ac­tive an­tibi­ot­ic pro­grams, ac­cord­ing to Na­ture Biotech­nol­o­gy. Oth­er small­er com­pa­nies de­vel­op­ing an ar­moury against mul­ti-drug re­sis­tant pathogens in­clude Cidara Ther­a­peu­tics $CDTX, Spero Ther­a­peu­tics $SPRO, Achao­gen $AKAO, and Macrolide Phar­ma­ceu­ti­cals. Sci­en­tists are al­so re­viv­ing re­search in­to decades-old idea to com­bat bac­te­ria us­ing the once-dis­missed bac­te­rio­phage ther­a­py.


Pfiz­er’s Doug Gior­dano has $500M — and some ad­vice — to of­fer a cer­tain breed of 'break­through' biotech

So let’s say you’re running a cutting-edge, clinical-stage biotech, probably public, but not necessarily so, which could see some big advantages teaming up with some marquee researchers, picking up say $50 million to $75 million dollars in a non-threatening minority equity investment that could take you to the next level.

Doug Giordano might have some thoughts on how that could work out.

The SVP of business development at the pharma giant has helped forge a new fund called the Pfizer Breakthrough Growth Initiative. And he has $500 million of Pfizer’s money to put behind 7 to 10 — or so — biotech stocks that fit that general description.

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Fangliang Zhang, AP Images

UP­DAT­ED: Leg­end fetch­es $424 mil­lion, emerges as biggest win­ner yet in pan­dem­ic IPO boom as shares soar

Amid a flurry of splashy pandemic IPOs, a J&J-partnered Chinese biotech has emerged with one of the largest public raises in biotech history.

Legend Biotech, the Nanjing-based CAR-T developer, has raised $424 million on NASDAQ. The biotech had originally filed for a still-hefty $350 million, based on a range of $18-$20, but managed to fetch $23 per share, allowing them to well-eclipse the massive raises from companies like Allogene, Juno, Galapagos, though they’ll still fall a few dollars short of Moderna’s record-setting $600 million raise from 2018.

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As it hap­pened: A bid­ding war for an an­tibi­ot­ic mak­er in a mar­ket that has rav­aged its peers

In a bewildering twist to the long-suffering market for antibiotics — there has actually been a bidding war for an antibiotic company: Tetraphase.

It all started back in March, when the maker of Xerava (an FDA approved therapy for complicated intra-abdominal infections) said it had received an offer from AcelRx for an all-stock deal valued at $14.4 million.

The offer was well-timed. Xerava was approved in 2018, four years after Tetraphase posted its first batch of pivotal trial data, and sales were nowhere near where they needed to be in order for the company to keep its head above water.

RA Cap­i­tal, Hill­house join $310M rush to back Ever­est's climb to com­mer­cial heights in Chi­na

Money has never been an issue for Everest Medicines. With an essentially open tab from their founders at C-Bridge Capital, the biotech has gone two and a half years racking up drug after drug, bringing in top exec after top exec, and issuing clinical update after update.

But now other investors want in — and they’re betting big.

Everest is closing its Series C at $310 million. The first $50 million comes from the Jiashan National Economic and Technological Development Zone; the remaining C-2 tranche was led by Janchor Partners, with RA Capital Management and Hillhouse Capital as co-leaders. Decheng Capital, GT Fund, Janus Henderson Investors, Rock Springs Capital, Octagon Investments all joined.

Por­tion of Neil Wood­ford’s re­main­ing in­vest­ments, in­clud­ing Nanopore, sold off for $284 mil­lion

It’s been precisely one year and one day since Neil Woodford froze his once-vaunted fund, and while a global pandemic has recently shielded him from the torrent of headlines, the fallout continues.

Today, the California-based patent licensing firm Acacia Research acquired the fund’s shares for 19 healthcare and biotech companies for $284 million.  Those companies include shares for public and private companies and count some of Woodford’s most prominent bio-bets, such as Theravance Biopharma, Oxford Nanopore and Mereo Biopharma, according to Sky News, which first reported the sale. It won’t include shares for BenevelontAI, the machine learning biotech once valued at $2 billion.

Drug man­u­fac­tur­ing gi­ant Lon­za taps Roche/phar­ma ‘rein­ven­tion’ vet as its new CEO

Lonza chairman Albert Baehny took his time headhunting a new CEO for the company, making it absolutely clear he wanted a Big Pharma or biotech CEO with a good long track record in the business for the top spot. In the end, he went with the gold standard, turning to Roche’s ranks to recruit Pierre-Alain Ruffieux for the job.

Ruffieux, a member of the pharma leadership team at Roche, spent close to 5 years at the company. But like a small army of manufacturing execs, he gained much of his experience at the other Big Pharma in Basel, remaining at Novartis for 12 years before expanding his horizons.

Leen Kawas, Athira CEO (Athira)

Can a small biotech suc­cess­ful­ly tack­le an Ever­est climb like Alzheimer’s? Athi­ra has $85M and some in­flu­en­tial back­ers ready to give it a shot

There haven’t been a lot of big venture rounds for biotech companies looking to run a Phase II study in Alzheimer’s.

The field has been a disaster over the past decade. Amyloid didn’t pan out as a target — going down in a litany of Phase III failures — and is now making its last stand at Biogen. Tau is a comer, but when you look around and all you see is destruction, the idea of backing a startup trying to find complex cocktails to swing the course of this devilishly complicated memory-wasting disease would daunt the pluckiest investors.

Covid-19 roundup: Ab­b­Vie jumps in­to Covid-19 an­ti­body hunt; As­traZeneca shoots for 2B dos­es of Ox­ford vac­cine — with $750M from CEPI, Gavi

Another Big Pharma is entering the Covid-19 antibody hunt.

AbbVie has announced a collaboration with the Netherlands’ Utrecht University and Erasmus Medical Center and the Chinese-Dutch biotech Harbour Biomed to develop a neutralizing antibody that can treat Covid-19. The antibody, called 47D11, was discovered by AbbVie’s three partners, and AbbVie will support early preclinical work, while preparing for later preclinical and clinical development. Researchers described the antibody in Nature Communications last month.

Michael Gladstone, partner at Atlas Venture

At­las rais­es new $400M fund amid spree of VC rais­es. Here’s what they’ll spend it on

You can add another few hundred million to the now Montana-sized reservoir of cash biotech VCs have raised since the WHO declared Covid-19 a pandemic.

Atlas Venture, the prominent Kendall Square incubator, has raised $400 million for its twelfth biotech fund, their first in 3 years. After a string of mammoth new raises from other major VCs in April and May, the total pot now stands between $5 billion and $6 billion, depending on how you slice it.

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