Narcan maker Opiant shelves bulimia program after mid-stage flop
Narcan maker Opiant Pharmaceuticals has admitted defeat in a mid-stage trial testing a nasal spray version of naloxone in patients with bulimia, prompting the California-based company to abandon the development of the formulation altogether.
The Phase II trial tested the drug — OPNT001 — against a placebo in 86 patients with bulimia. The potentially life-threatening, addictive eating disorder is typically seen in women, and is characterized by a cycle of binging and compensatory behaviors such as self-induced vomiting, fasting, excessive exercise or misusing laxatives to make up for the gluttony. Cognitive behavioral therapy is considered the primary treatment for bulimia, according to the British Medical Journal.
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