Brett Monia, Ionis CEO

Near­ly 70% of Akcea's work­force is on the chop­ping block as Io­n­is ex­e­cutes ma­jor re­struc­tur­ing

About half a year af­ter re­ab­sorb­ing its lipid-fo­cused spin­out Akcea, Io­n­is is now putting a ma­jor re­or­ga­ni­za­tion plan in play — one that in­volves shav­ing near­ly 70% of the sub­sidiary’s work­force and ex­pand­ing its dis­tri­b­u­tion deal with So­bi.

Akcea be­gan as a whol­ly-owned sub­sidiary back in 2014, be­fore Io­n­is put about a quar­ter of its shares on the pub­lic mar­kets. In its 2017 pub­lic de­but, Akcea raised $125 mil­lion, plus an­oth­er $50 mil­lion in a pri­vate place­ment with No­var­tis. Then in Au­gust, Io­n­is paid about $500 mil­lion — $18.15 per share — to buy that quar­ter back.

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