News brief­ing: Take­da re­ports PhI­II fail­ure for Nin­laro in mul­ti­ple myelo­ma; As­traZeneca plots piv­ot to Nas­daq

Take­da’s plans for Nin­laro have hit a road block.

The phar­ma gi­ant re­port­ed Thurs­day that its Phase III study adding their drug to lenalido­mide and dex­am­etha­sone has failed against a place­bo com­bo us­ing the in­dus­try stan­dards for mul­ti­ple myelo­ma.

The triplet failed, reg­is­ter­ing a 13.5-month in­crease in me­di­an pro­gres­sion-free sur­vival, 35.3 months com­pared to 21.8 months for the sug­ar pill ad­di­tion. That was not sta­tis­ti­cal­ly sig­nif­i­cant. The p val­ue was 0.073.

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