On heels of Aduhelm ap­proval, Bris­tol My­ers jumps back in­to Alzheimer's race

Bris­tol My­ers Squibb last put ma­jor re­sources be­hind an Alzheimer’s drug near­ly a decade ago, when their own at­tempt at tar­get­ing amy­loid flamed out in mid-stage stud­ies. They in­vent­ed an­oth­er mol­e­cule, a tau-tar­get­ed an­ti­body, but jet­ti­soned it to Bio­gen in 2017 as they dropped out of neu­ro­science al­to­geth­er.

But on Thurs­day, the New York phar­ma an­nounced they were get­ting back in the game. Bris­tol My­ers ex­er­cised an $80 mil­lion op­tion to bring a tau-tar­get­ed an­ti­body from Prothena in­to a Phase I study. The opt-in, which Bris­tol My­ers trig­gered ahead of an­a­lyst ex­pec­ta­tions, opens the door for an­oth­er $1.7 bil­lion in mile­stones down the road.

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