Alexis Dormandy, Oxford Science Enterprises CEO

Ox­ford Sci­ence En­ter­pris­es col­lects $300M to of­fer spin­outs 's­cale-up cap­i­tal'

For the past sev­en years, biotech spin­outs from the Uni­ver­si­ty of Ox­ford have of­ten tapped in­to a re­li­able source of in­vest­ments from Ox­ford Sci­ence En­ter­pris­es, the com­pa­ny tasked with found­ing, fund­ing and build­ing star­tups based on “ex­cep­tion­al sci­ence” flow­ing out of Ox­ford.

And the pool has got­ten $300 mil­lion (£250 mil­lion) deep­er as Ox­ford Sci­ence En­ter­pris­es bags a new raise that puts its tal­ly over $1 bil­lion (£850 mil­lion).

Life sci­ences isn’t the on­ly fo­cus of Ox­ford Sci­ence En­ter­pris­es — there’s al­so health tech and deep tech vy­ing for at­ten­tion — but drug de­vel­op­ers may take par­tic­u­lar de­light in its plans to de­ploy “in­creas­ing­ly large amounts of cap­i­tal in lat­er-stage fund­ing rounds.”

With port­fo­lio com­pa­nies ma­tur­ing and get­ting clos­er to promised break­throughs in can­cer, heart fail­ure and in­fec­tious dis­eases along­side cli­mate change, food se­cu­ri­ty and quan­tum com­put­ing, such “scale-up cap­i­tal” will be in­creas­ing­ly cru­cial, said CEO Alex­is Dor­mandy.

“This fundraise comes at an ex­cit­ing and piv­otal time for OSE,” he said in a state­ment. “Over the next few years, we ex­pect these com­pa­nies will con­tin­ue to make im­por­tant progress; with our on­go­ing ef­forts, and the sup­port of our share­hold­ers, we look for­ward to help­ing them de­liv­er im­pact and re­turns.”

Ox­ford Sci­ence En­ter­pris­es likes to tout its found­ing in­vestor role in Vac­citech, the vac­cine de­vel­op­er that played a con­sid­er­able role in As­traZeneca’s Covid-19 shot.

More re­cent­ly, the com­pa­ny backed Miro­Bio’s $97 mil­lion Se­ries B, de­signed to test a pipeline of check­point ag­o­nists — think the re­verse of PD-1 in­hibitors — as treat­ments of au­toim­mune dis­eases. It al­so joined the $100 mil­lion round for OMass Ther­a­peu­tics, which is fo­cused on im­munol­o­gy and rare dis­eases. Over the years, it’s in­vest­ed in about 80 com­pa­nies, whose work runs the gamut from can­cer de­tec­tion to her­bi­cides to en­er­gy pro­duc­tion.

On top of fund­ing, it al­so sup­ports port­fo­lio com­pa­nies by con­nect­ing them to a net­work of ad­vi­sors and of­fer­ing lab and of­fice space.

While the in­vestors for the new raise were not dis­closed, Ox­ford Sci­ence En­ter­pris­es not­ed they com­prise “ex­ist­ing and new blue-chip in­vestors, sov­er­eign wealth funds, fam­i­ly of­fices, pen­sion funds and as­set man­agers.”

Biotech in­vestors and CEOs see two paths to growth, but are they equal­ly vi­able?

The dynamic in the biotech market has been highly volatile in the last few years, from the high peaks immediately after the COVID vaccine in 2021, to the lowest downturns of the last 20 years in 2022. This uncertainty makes calling the exact timing of the market’s turn something of a fool’s errand, according to Dr. Chen Yu, Founder and Managing Partner of TCG Crossover (TCG X). He speaks with RBC’s Noël Brown, Head of US Biotechnology Investment Banking, about the market’s road ahead and two possible paths for growth.

Casey McPherson shows his daughters Rose (left) and Weston around Everlum Bio, a lab that he co-founded to spark a treatment for Rose and others with ultra-rare conditions. (Ilana Panich-Linsman)

Fa­ther starts lab af­ter in­tel­lec­tu­al prop­er­ty is­sues stymie rare dis­ease drug de­vel­op­ment

Under bright lab lights, Casey McPherson holds his 6-year-old daughter, Rose. His free hand directs Rose’s gaze toward a computer screen with potential clues in treating her one-of-a kind genetic condition.

Gray specks on the screen show her cells that scientists reprogrammed with the goal of zeroing in on a custom medicine. McPherson co-founded the lab, Everlum Bio, to spark a treatment for Rose — and others like her. A regarded singer-songwriter, McPherson never imagined going into drug development.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 150,300+ biopharma pros reading Endpoints daily — and it's free.

Benjamine Liu, TrialSpark CEO

Paul Hud­son and Tri­alSpark's mu­tu­al de­sire to speed up de­vel­op­ment con­verges in three-year, six-drug goal

A unicorn startup that originally set out to hasten clinical studies for biopharma partners dug further into its revised path of internal drug development by linking arms with Sanofi in a pact that the biotech’s CEO said originated from the top.

TrialSpark and the Big Pharma on Tuesday committed to in-licensing and/or acquiring six Phase II/Phase III drugs within the next three years.

“I’ve known Paul Hudson for a while and we were discussing the opportunity to really re-imagine a lot of different parts of pharma,” TrialSpark CEO Benjamine Liu told Endpoints News, “and one of the things that we discussed was this opportunity to accelerate the development of new medicines in mutual areas of interest.”

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 150,300+ biopharma pros reading Endpoints daily — and it's free.

Look­ing to push CAR-T in sol­id tu­mors, Bay Area biotech goes pub­lic in SPAC flip — with slight name change

SPACs might be slowly creeping back.

Monday evening, Estrella Biopharma said it was going public via a SPAC deal with TradeUP Acquisition Corp. The deal is set to close in the first half of 2023, and if all goes as planned, the public version of Estrella — dubbed Estrella Immunopharma — will be worth around $398.5 million.

The Bay Area biotech will also get around $45.4 million in cash, and TradeUp stockholders will get around 15% stock in the public biotech.

Take­da to pull key hy­poparathy­roidism drug from the mar­ket en­tire­ly by end of 2024 af­ter years of man­u­fac­tur­ing woes

Takeda on Tuesday morning made an announcement that almost 3,000 people with the rare disease known as hypoparathyroidism were fearing.

Due to unresolved supply issues and manufacturing woes, Takeda said it will cut its losses and discontinue its hypoparathyroidism drug, known as Natpara (parathyroid hormone), halting all manufacturing of the drug by the end of 2024.

The decision to not re-commercialize Natpara will be a blow to not only the 2,400 people who were awaiting supplies of their reliable injection since 2019, but also the additional nearly 400 people who were accessing the drugs via the company’s Special Use Program as Takeda sought to resolve these manufacturing issues over the past five years.

Marc Dunoyer, Alexion CEO (AstraZeneca via YouTube)

Up­dat­ed: As­traZeneca nabs a small rare dis­ease gene ther­a­py play­er for 667% pre­mi­um

AstraZeneca is kicking off the fourth quarter with a little M&A Monday for a gene editing player recently overcoming a second clinical hold to its only program in human studies.

The Big Pharma and its subsidiary Alexion are buying out little LogicBio for $2.07 per share. That’s good for a massive 667% premium over its Friday closing price, when it headed into the weekend at 27 cents and just weeks after Nasdaq said LogicBio would have to delist, which has been put on hold as the biotech requests a hearing. It’s one of two biotech deals to commence October, alongside the news of Incyte buying a vitiligo-focused biotech.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 150,300+ biopharma pros reading Endpoints daily — and it's free.

Dave Marek, Myovant CEO

My­ovant board balks as ma­jor­i­ty own­er Sum­it­o­mo swoops in with a $2.5B deal to buy them out

Three years after Sumitomo scooped up Roivant’s 46% stake in the publicly traded Myovant $MYOV as part of a 5-company, $3 billion deal, they’re coming back for the whole thing.

But these other investors at Myovant want more than what the Japanese pharma company is currently offering to pay at this stage.

Sumitomo is bidding $22.75 a share for the outstanding stock, which now represents 48% of the company after Sumitomo bumped its ownership since the original deal with Roivant. Myovant, however, created a special committee on the board, and they’re shaking their heads over the offer.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 150,300+ biopharma pros reading Endpoints daily — and it's free.

Astel­las, Pan­th­er­na add or­gan to mR­NA tie-up; Rock­et launch­es sale of six fig­ures worth of stock

Astellas and Pantherna have expanded their November 2021 pact surrounding the latter’s mRNA platform to include a new target organ, the duo announced Tuesday morning, though they did not specify what that target is.

German biotech Pantherna is home to two platform technologies — one that designs mRNAs for non-vaccine therapies and another that designs LNPs. Astellas and Pantherna’s deal appears to mainly revolve around the first platform, which Astellas said it is using to research direct reprogramming, or turning cells from one kind into another without an intermediate stem cell phase.

Andrew Crockett, KalVista CEO

KalVista ends a PhII study ear­ly af­ter pa­tients suf­fer se­vere and life-threat­en­ing side ef­fects

KalVista took a beating Tuesday after announcing it would scrap a Phase II trial for one of its experimental drugs.

The biotech said in an early morning press release that it is terminating the study for KVD824 after multiple patients in every treatment group saw unsafe, elevated levels of certain liver enzymes. By ending the trial now, KalVista hopes to save some money and funnel it toward another study for its lead program, CEO Andrew Crockett said in a statement.