Pa­tient deaths force Astel­las to write off $540M of their $3B gene ther­a­py buy­out as time­line grows and tar­get group shrinks

Astel­las no longer be­lieves that last year’s $3 bil­lion ac­qui­si­tion is worth $3 bil­lion.

The Japan­ese phar­ma post­ed a no­tice on its web­site Tues­day dis­clos­ing that they had writ­ten off $540 mil­lion af­ter the lead gene ther­a­py they ac­quired in the Au­dentes buy­out faced trag­ic set­backs. Astel­las said the re-ap­praisal came af­ter they de­ter­mined that the ther­a­py, a one-time treat­ment for the rare and fa­tal mus­cle-wast­ing X-linked my­otubu­lar my­opa­thy, would be ap­proved lat­er than they orig­i­nal­ly ex­pect­ed and for a small­er pa­tient pop­u­la­tion.

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