Pfiz­er lines up an $830M al­liance with Arv­inas on pro­tein degra­da­tion

Arv­inas has lined up its third Big Phar­ma part­ner for a trip down the dis­cov­ery path of pro­tein degra­da­tion.

Sean Cas­sidy

Pfiz­er has signed on to fund the launch of a hunt for a slate of small mol­e­cules that can de­grade pro­teins, a key ther­a­peu­tic path­way that’s been play­ing a role in prostate can­cer and oth­er ar­eas.

Like a lot of Pfiz­er $PFE pacts, the news comes with on­ly a few snip­pets of in­for­ma­tion. We don’t know the up­front, but the over­all pack­et of mile­stones adds up to a whop­ping $830 mil­lion for un­bri­dled suc­cess. To­tal num­ber of pro­grams in­volved? No idea. Dis­ease fo­cus­es? Uh-uh.

Arv­inas has signed two oth­er ma­jor al­liances with mar­quee phar­mas, ink­ing deals with Genen­tech and Mer­ck ear­li­er. And Genen­tech came back last No­vem­ber to dou­ble down on the re­la­tion­ship, push­ing the mile­stones up to $650 mil­lion.

While the de­tails are few and far be­tween, CFO Sean Cas­sidy tells me that the re­la­tion­ship is a big plus for the biotech, help­ing them as­sert boast­ing rights as the leader in a field that al­so in­cludes C4 Ther­a­peu­tics — out of Jay Brad­ner’s lab at Dana Far­ber be­fore he took the helm at NI­BR — and the start­up Kymera. And not sur­pris­ing­ly, Brad­ner re­cent­ly forged a close re­la­tion­ship with UC San Fran­cis­co on pro­tein degra­da­tion as well.

The sci­en­tif­ic con­cept is sim­ple enough. In­stead of set­tling for pro­tein in­hi­bi­tion, the big idea here is that degra­da­tion and dis­pos­al through the ubiq­ui­tin-pro­tea­some sys­tem of­fers a more durable ap­proach to fight­ing dis­eases. And it’s been in­creas­ing­ly pop­u­lar in the in­dus­try.

The staff at Arv­inas, around 50 now, is slat­ed to grow to 75 over the next year.

Arv­inas has been work­ing on its own in­ter­nal pipeline while work­ing with its col­lab­o­ra­tors. One of these projects in­cludes a fo­cus on tau for Alzheimer’s, one of the tox­ic con­cen­tra­tions of­ten fin­gered as a cul­prit in the dis­ease.

A fa­vorite in Alex­ion’s C-suite is leav­ing, and some mighty sur­prised an­a­lysts aren’t the least bit hap­py about it

Analysts hate to lose a biotech CFO they’ve come to trust and admire — especially if they’re being blindsided by a surprise exit.

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David Grainger [file photo]

'Dis­con­nect the bas­tard­s' — one biotech's plan to break can­cer cell­s' uni­fied de­fens­es

Chemotherapy and radiotherapy are the current gladiators of cancer treatment, but they come with well-known limitations and side-effects. The emergence of immunotherapy — a ferocious new titan in oncologist’s toolbox — takes the brakes off the immune system to kill cancer cells with remarkable success in some cases, but the approach is not always effective. What makes certain forms of cancer so resilient? Scientists may have finally pieced together a tantalizing piece of the puzzle, and a new biotech is banking on a new approach to fill the gap.

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While No­var­tis ban­ish­es Zol­gens­ma scan­dal scars — Bio­gen goes on a Spin­raza 'of­fen­sive'

While Novartis painstakingly works to mop up the stench of the data manipulation scandal associated with its expensive gene therapy for spinal muscular atrophy (SMA) Zolgensma— rival Biogen is attempting to expand the use of its SMA therapy, Spinraza. 

The US drugmaker $BIIB secured US approval for Spinraza for use in the often fatal genetic disease in 2016. The approval covered a broad range of patients with infantile-onset (most likely to develop Type 1) SMA. 

Jason Kelly. Mike Blake/Reuters via Adobe

Eye­ing big ther­a­peu­tic push, Gink­go bags $290M to build a cell pro­gram­ming em­pire

Ginkgo Bioworks is on a roll. Days after publicizing a plan to nurture new startups via partnerships with accelerators Y Combinator and Petri, the Boston biotech says it has raised another $290 million for its cell programming platform to reach further and wider.

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UP­DAT­ED: Speak­er Nan­cy Pelosi to un­veil bill for fed­er­al­ly ne­go­ti­at­ed drug prices

After months of buzz from both sides of the aisle, Speaker Nancy Pelosi will today introduce her plan to allow the federal government to negotiate prices for 250 prescription drugs, setting up a showdown with a pharmaceutical industry working overtime to prevent it.

The need to limit drug prices is a rare point of agreement between President Trump and Democrats, although the president has yet to comment on the proposal and will likely face pressure to back a more conservative option or no bill at all. Republican Senator Chuck Grassley is reportedly lobbying his fellow party members on a more modest proposal he negotiated with Democratic Senator Ron Wyden in July.

Jeff Kindler's Cen­trex­ion re­news bid to make pub­lic de­but

Jeffrey Kindler’s plan to take his biotech — which is developing a slate of non-opioid painkillers — public, is back on.

The Boston based company, led by former Pfizer $PFE chief Kindler, originally contemplated a $70 million to $80 million IPO last year— but eventually postponed that strategy. On Wednesday, the company revived its bid to make a public debut in a filing with the SEC — although no pricing details were disclosed.

Zachary Hornby. Boundless

'A fourth rev­o­lu­tion in can­cer ther­a­pies': ARCH-backed Bound­less Bio flash­es big check, makes big­ger promis­es in de­but

It was the cellular equivalent of opening your car door and finding an active, roaring engine in the driver seat.

Scientists learned strands of DNA could occasionally appear outside of its traditional home in the nucleus in the 1970s, when they appeared as little, innocuous circles on microscopes; inexplicable but apparently innate. But not until UC San Diego’s Paul Mischel published his first study in Science in 2014 did researchers realize these circles were not only active but potentially overactive and driving some cancer tumors’ superhuman growth.

It’s fi­nal­ly over: Bio­gen, Ei­sai scrap big Alzheimer’s PhI­I­Is af­ter a pre­dictable BACE cat­a­stro­phe rais­es safe­ty fears

Months after analysts and investors called on Biogen and Eisai to scrap their BACE drug for Alzheimer’s and move on in the wake of a string of late-stage failures and rising safety fears, the partners have called it quits. And they said they were dropping the drug — elenbecestat — after the independent monitoring board raised concerns about…safety.

We don’t know exactly what researchers found in this latest catastrophe, but the companies noted in their release that investigators had determined that the drug was flunking the risk/benefit analysis.

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Mer­ck helps bankroll new part­ner Themis' game plan to fin­ish the chikun­gun­ya race and be­gin on­colyt­ic virus quest

As Themis gears up for a Phase III trial of its chikungunya vaccine, the Vienna-based biotech has closed out €40 million ($44 million) to foot the clinical and manufacturing bills.

Its heavyweight partners at Merck — which signed a pact around a mysterious “blockbuster indication” last month — jumped into the Series D, led by new investors Farallon Capital and Hadean Ventures. Adjuvant Capital also joined, as did current investors Global Health Investment Fund, aws Gruenderfonds, Omnes Capital, Ventech and Wellington Partners Life Sciences.