PhRMA diss­es Marathon CEO—and PhRMA board mem­ber—Jeff Aronin af­ter lat­est price goug­ing con­tro­ver­sy

Af­ter main­tain­ing a stead­fast si­lence for the past five days, PhRMA is cut­ting Jeff Aronin loose.

The Marathon CEO and PhRMA board mem­ber trig­gered a tem­pest over his an­nounce­ment last Thurs­day evening that he would price his new­ly ap­proved steroid — a cheap, gener­ic of­fer­ing sold in many coun­tries around the world as de­flaza­cort — for $89,000 a year af­ter land­ing an ap­proval to mar­ket it for Duchenne mus­cu­lar dy­s­tro­phy. Ac­cord­ing to a num­ber of pa­tient ad­vo­cates, they’ve been buy­ing the drug from over­seas for about $1,000 a year.

On Mon­day Sen­a­tor Bernie Sanders and Con­gress­man Eli­jah Cum­mings ac­cused Aronin and Marathon of rip­ping off the sys­tem in the lat­est ex­am­ple of a drug ex­ec­u­tive look­ing to cash in af­ter gam­ing the FDA’s ap­proval process. Now PhRMA says Marathon is guilty of con­duct un­be­com­ing to the in­dus­try, launch­ing a re­view on mem­ber­ship cri­te­ria that would like­ly leave Aronin in the cold.

Their state­ment tonight:

We are pleased Marathon de­cid­ed to pause the launch of their med­i­cine to so­lic­it ad­di­tion­al in­put from pa­tients and oth­er stake­hold­ers. Their re­cent ac­tions are not con­sis­tent with the mis­sion of our or­ga­ni­za­tion. In ad­di­tion, the lead­er­ship of the PhRMA Board of Di­rec­tors has be­gun a com­pre­hen­sive re­view of our mem­ber­ship cri­te­ria to en­sure we are fo­cused on rep­re­sent­ing re­search-based bio­phar­ma­ceu­ti­cal com­pa­nies who take sig­nif­i­cant risks to bring new treat­ments and cures to pa­tients.

This is just the lat­est in a se­ries of em­bar­rass­ing con­tro­ver­sies cen­tered on charges of price goug­ing. Tur­ing CEO Mar­tin Shkre­li got it start­ed. Valeant was quick­ly swept up. And then My­lan took a turn in the pub­lic stocks. Now it’s Marathon’s time to stand in the spot­light.

Aronin protest­ed to Duchenne par­ents last Fri­day that the com­pa­ny did “heavy lift­ing” in its R&D pro­gram that jus­ti­fied the price. The re­search made valu­able con­tri­bu­tions to un­der­stand­ing the drug, he added, leav­ing the com­pa­ny in a hole that would take years to ex­tri­cate it­self from. But tri­al ex­perts told me that the kind of R&D pro­gram that Marathon did could be eas­i­ly cov­ered by a year’s worth of rev­enue from just a slice of the po­ten­tial mar­ket that he hoped to sell to.

By Wednes­day night Aronin was more of a li­a­bil­i­ty to PhRMA than a ben­e­fit. Just weeks ago the trade group be­gan an am­bi­tious mar­ket­ing cam­paign aimed at high­light­ing the con­tri­bu­tions of med­ical re­search. It was time, said PhRMA CEO Stephen Ubl in a thin­ly veiled jab at Shkre­li, for more lab coats and few­er hood­ies.

At the time, Shkre­li fired back that he had learned every­thing about rais­ing prices from Marathon.

For now, Aronin re­mains on the board at PhRMA. But his odds of mak­ing it much longer aren’t good. Marathon did not im­me­di­ate­ly re­spond to a query. And Aronin has con­sis­tent­ly re­fused to take a call from me.

IDC: Life Sci­ences Firms Must Em­brace Dig­i­tal Trans­for­ma­tion Now

Pre-pandemic, the life sciences industry had settled into a pattern. The average drug took 12 years and $2.9 billion to bring to market, and it was an acceptable mode of operations, according to Nimita Limaye, Research Vice President for Life Sciences R&D Strategy and Technology at IDC.

COVID-19 changed that, and served as a proof-of-concept for how technology can truly help life sciences companies succeed and grow, Limaye said. She recently spoke about industry trends at Egnyte’s Life Sciences Summit 2022. You should watch the entire session, free and on-demand, but here’s a brief recap of why she’s urging life sciences companies to embrace digital transformation.

James Mock, incoming CFO at Moderna

Mod­er­na taps new CFO from PerkinElmer af­ter for­mer one-day CFO oust­ed

When Moderna hired a new CFO last year,  it didn’t expect to see him gone after only one day. Today the biotech named his — likely much more vetted — replacement.

The mRNA company put out word early Wednesday that after the untimely departure of then brand-new CFO Jorge Gomez, it has now found a replacement in James Mock, the soon-to-be former CFO at diagnostics and analytics company PerkinElmer.

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Bayer's first DTC ad campaign for chronic kidney disease drug Kerendia spells out its benefits

Bay­er aims to sim­pli­fy the com­plex­i­ties of CKD with an ABC-themed ad cam­paign

Do you know the ABCs of CKD in T2D? Bayer’s first ad campaign for Kerendia tackles the complexity of chronic kidney disease with a play on the acronym (CKD) and its connection to type 2 diabetes (T2D).

Kerendia was approved last year as the first and only non-steroidal mineralocorticoid receptor antagonist to treat CKD in people with type 2 diabetes.

In the TV commercial launched this week, A is for awareness, B is for belief and C is for cardiovascular, explained in the ad as awareness of the connection between type 2 and kidney disease, belief that something can be done about it, and cardiovascular events that may be reduced with treatment.

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Tom Barnes, Orna Therapeutics CEO

UP­DAT­ED: 'We have failed to fail': Mer­ck gam­bles $250M cash on a next-gen ap­proach to mR­NA — af­ter punt­ing its big al­liance with Mod­er­na

Merck went in deep on its collaboration with Moderna on new mRNA programs, and dropped them all over time, including their RSV partnership. But after writing off what turned out as one of the most successful infectious disease players in the business, Merck is coming in this morning with a new preclinical alliance — this time embracing a biotech that hopes to eventually outdo the famously successful mRNA in a new run at vaccines and therapeutics.

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Joe Jonas (Photo by Anthony Behar/Sipa USA)(Sipa via AP Images)

So­lo Jonas broth­er car­ries Merz's new tune in Botox ri­val cam­paign

As the lyrics of his band’s 2019 pop-rock single suggests, Joe Jonas is only human — and that means even he gets frown lines. The 33-year-old singer-songwriter is Merz’s newest celebrity brand partner for its Botox rival Xeomin, as medical aesthetics brands target a younger audience.

Merz kicked off its “Beauty on Your Terms” campaign on Tuesday, featuring the Jonas brother in a video ad for its double-filtered anti-wrinkle injection Xeomin.

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Paul Perreault, CSL Behring CEO

CSL CEO Paul Per­reault de­ter­mined to grow plas­ma col­lec­tion af­ter full-year sales dip

As the ink dries on CSL’s $11.7 billion Vifor buyout, the company posted a dip in profits, due in part to a drop in plasma donations amid the pandemic.

However, CEO Paul Perreault assured investors and analysts on the full-year call that the team has left “no stone unturned” when assessing options to grow plasma volumes. The chief executive also spelled out positive results for the company’s monoclonal antibody garadacimab in hereditary angioedema (HAE), though he isn’t revealing the exact numbers just yet.

Blaise Coleman, Endo International CEO

En­do files for Chap­ter 11 as it looks to fin­ish off its opi­oid lit­i­ga­tion

Irish drugmaker Endo International is entering into bankruptcy as it faces the weight of serious litigation related to its involvement in the opioid epidemic in the US.

The company has filed Chapter 11 proceedings in the US Bankruptcy Court for the Southern District of New York, with the company expected to file recognition proceedings in Canada, the UK and Australia. The company’s bankruptcy filing showed the company had assets and liabilities in the range of $1 billion to $10 billion.

Etleva Kadilli, director of UNICEF’s supply division

GSK lands first-ever UNICEF con­tract for malar­ia vac­cine worth $170M

GSK has landed a new first from UNICEF the first-ever contract for malaria vaccines, worth up to $170 million for 18 million vaccine doses distributed over the next three years.

The vaccine, known as Mosquirix or RTS,S, won WHO’s backing last October after a controversial start, but UNICEF said these doses will potentially save thousands of lives every year.

“We hope this is just the beginning,” Etleva Kadilli, director of UNICEF’s supply division, said. “Continued innovation is needed to develop new and next-generation vaccines to increase available supply, and enable a healthier vaccine market. This is a giant step forward in our collective efforts to save children’s lives and reduce the burden of malaria as part of wider malaria prevention and control programmes.”

Governor John Carney, Lieutenant Governor Bethany Hall-Long, Mayor Kenneth Branner, Jr., Delaware Prosperity Partnership President Kurt Foreman, WuXi AppTec Chairman and CEO Ge Li, WuXi AppTec Co-CEO and WuXi STA CEO Minzhang Chen, and others celebrate the groundbreaking for the WuXi STA Middletown campus.

WuXi breaks ground on Delaware fa­cil­i­ty, boost­ing its US pres­ence

While Middletown, Delaware’s main claim to fame was the site location for the film the Dead Poets Society, the city will soon play host to a massive manufacturing outfit.

WuXi AppTec’s contract research and manufacturing subsidiary WuXi STA, has broken ground on a 190-acre manufacturing campus in Middletown.

According to the company, this site will be WuXi’s second facility in the US, and it will create around 500 full-time jobs by 2026, but there are plans to kick off operations in 2025.