Ra Pharma puts its best foot forward with PhII Soliris rival, but shares crash after comparison to Alexion’s next-gen drug
Early this morning, investigators for Cambridge, MA-based Ra Pharmaceuticals $RARX put their best foot forward when they rolled out interim Phase II data for their rival to Soliris, Alexion’s $ALXN powerfully pricey therapy for paroxysmal nocturnal hemoglobinuria, or PNH.
The data looked good for the patients who were Soliris-naive, with 8 of 10 staying on therapy. In a tiny group of 5 patients in the transfusion-independent group who switched from Soliris to RA101495, LDH levels were stable with no episodes of breakthrough hemolysis. Seven of the 11 hard-to-treat Soliris patients did experience hemolysis, though, when they converted to the experimental drug and switched back.
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