Retrophin beefs up the rare dis­ease drug pipeline with a $517M buy­out deal

A lit­tle more than a year af­ter Retrophin con­ced­ed the com­plete fail­ure of a drug co-in­vent­ed by com­pa­ny founder Mar­tin Shkre­li, the biotech is beef­ing up its rare dis­ease pipeline through a $517 mil­lion buy­out deal — front­ed with $90 mil­lion in cash.

Af­ter the bell sound­ed Thurs­day, Retrophin $RTRX put out word that it’s ac­quir­ing the low-pro­file biotech Or­phan Tech­nolo­gies. The buy­out gives them an en­zyme re­place­ment ther­a­py called OT-58 for the treat­ment of clas­si­cal ho­mo­cystin­uria, a rare dis­ease that is trig­gered by in­suf­fi­cient lev­els of an en­zyme called cys­tathio­n­ine be­ta syn­thase.

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