Henry Colecraft and Scott Kanner (via Columbia Technology Ventures)
Salvaging 'ugly fruit': After a series of protein degradation bets, Versant turns to protein stabilization platform out of Columbia
As an expert on ion channels, Henry Colecraft was familiar with the damage that an overzealous ubiquitination system can do to the body. While that process, often described as a garbage disposal mechanism, is crucial for getting rid of defective or unnecessary proteins, it can also mistakenly send still functional proteins to destruction.
It is a process involved in a diverse group of diseases known as ion channelopathies, ranging from cystic fibrosis to epilepsy to the heart disease known as long QT syndrome.
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