Swamy Vijayan. Plexium

San Diego up­start de­buts dis­cov­ery en­gine that puts a twist to pro­tein degra­da­tion

For years, the idea of pro­tein degra­da­tion — uti­liz­ing the cell’s nat­ur­al garbage dis­pos­al sys­tem to mark prob­lem­at­ic pro­teins for de­struc­tion — re­mained an el­e­gant but tech­ni­cal­ly dif­fi­cult con­cept. But now es­tab­lished as a promis­ing clin­i­cal strat­e­gy, with ma­jor bio­phar­ma play­ers such as Bay­er, Gilead and Ver­tex try­ing to grab a foothold via part­ner­ship deals, a San Diego start­up is look­ing to ex­ploit it and push its lim­its.

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